La professeure Cathy Vaillancourt détient un B.Sc. en biochimie (1990) de l’Université de Sherbrooke, et des diplômes de M.Sc. (1993) et de Ph. D. (1997) en sciences biomédicales, option obstétrique et gynécologie (1993) de l’Université de Montréal.
Elle a effectué un premier stage postdoctoral (1997-2000) dans le laboratoire de Dr Patricia Boksa au Centre de recherche de l’Hôpital Douglas de l’Université McGill et un deuxième stage postdoctoral (2000-2001) dans le laboratoire du Pr Philip Strange à l’Université de Reading en Angleterre Elle était alors boursière du FRSQ et des IRSC. Elle devient, en 2001, professeure de chimie et biochimie à l’Université de Moncton, puis professeure agrégée à l’INRS-Institut Armand Frappier en 2005. La professeure Cathy Vaillancourt est également professeure associée au Département de biochimie de l’Université de Sherbrooke.
Les travaux de recherche de la professeure Vaillancourt se concentrent sur les aspects associés à l’implication des contaminants environnementaux et des étapes de la grossesse sur la physiologie du placenta humain et, tout particulièrement, sur les systèmes sérotoninergiques et mélatoninergiques placentaires.
Publications
8435569
Cathy Vaillancourt
1
chicago-author-date
10
date
desc
1
title
https://rechercheciusssnim.ca/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22NK53NEXY%22%2C%22library%22%3A%7B%22id%22%3A8435569%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ok%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BOk%2C%20Linda%2C%20Leanne%20Ohlund%2C%20Amy%20M.%20Inkster%2C%20et%20al.%202025.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pone.0322090%26%23039%3B%26gt%3BEffect%20of%20depression%20and%20serotonin%20reuptake%20inhibitors%20antidepressant%20treatment%20during%20pregnancy%20on%20protein%20expression%20in%20the%20human%20placenta%3A%20A%20quantitative%20proteomics%20analysis%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BPLOS%20One%26lt%3B%5C%2Fi%26gt%3B%2020%20%2812%29%3A%20e0322090.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0322090.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D8435569%26amp%3Bdlkey%3D83WXZIHU%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20depression%20and%20serotonin%20reuptake%20inhibitors%20antidepressant%20treatment%20during%20pregnancy%20on%20protein%20expression%20in%20the%20human%20placenta%3A%20A%20quantitative%20proteomics%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Ok%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leanne%22%2C%22lastName%22%3A%22Ohlund%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%20M.%22%2C%22lastName%22%3A%22Inkster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kayleigh%20S.%20J.%22%2C%22lastName%22%3A%22Campbell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20S.%22%2C%22lastName%22%3A%22Pe%5Cu00f1aherrera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ursula%22%2C%22lastName%22%3A%22Brain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lekha%22%2C%22lastName%22%3A%22Sleno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wendy%20P.%22%2C%22lastName%22%3A%22Robinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amadou%22%2C%22lastName%22%3A%22Barry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tim%20F.%22%2C%22lastName%22%3A%22Oberlander%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathy%22%2C%22lastName%22%3A%22Vaillancourt%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Ayman%20A%22%2C%22lastName%22%3A%22Swelum%22%7D%5D%2C%22abstractNote%22%3A%22Depression%20is%20one%20of%20the%20most%20prevalent%20mental%20health%20disorders%20affecting%20pregnant%20individuals%2C%20and%20serotonin%20reuptake%20inhibitors%20%28SRIs%29%20are%20the%20most%20prescribed%20medications%20to%20treat%20depressive%20symptoms%20during%20pregnancy.%20Both%20depression%20and%20SRI%20exposure%20may%20have%20developmental%20impacts%2C%20and%20as%20randomizing%20exposures%20and%20non-treatment%20is%20not%20feasible%20in%20humans%2C%20distinguishing%20the%20effect%20of%20each%20factor%20often%20remains%20challenging.%20To%20date%2C%20much%20of%20what%20guides%20clinical%20practice%20stems%20from%20reports%20of%20pregnant%20individuals%20and%20fetal%5C%2Finfant%20outcomes%2C%20overlooking%20the%20significant%20role%20of%20the%20placenta%20in%20maintaining%20a%20healthy%20pregnancy%20and%20mother-fetal%20health.%20In%20this%20study%2C%20we%20explored%20the%20effect%20of%20depression%20and%20SRI%20antidepressant%20treatment%20during%20pregnancy%20on%20the%20placental%20proteome.%20A%20shotgun%20proteomics%20method%20with%20liquid%20chromatography%20and%20tandem%20mass%20spectrometry%20%28LC-MS%5C%2FMS%29%20was%20performed.%20A%20cohort%20of%20pregnant%20individuals%20%28n%5Cu2009%3D%5Cu200982%29%20was%20recruited%20in%20their%202%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20nd%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20trimester%2C%20and%20clinician-rated%20mood%20symptoms%20measured%20using%20the%20Hamilton%20Depression%20Rating%20Scale%20%28HAM-D%29%20were%20obtained%20from%20them%20during%20pregnancy%20to%20identify%20three%20exposure%20groups%3A%20non-depressed%3B%20depressed%5C%2Fnon-SRI-treated%3B%20depressed%5C%2FSRI-treated.%20Differential%20protein%20expression%20and%20over-representation%20analyses%20on%20the%20placentas%20of%20the%20group%20with%20depression%5C%2Fnon-SRI%20compared%20with%20placentas%20from%20healthy%20individuals%20showed%20an%20increase%20in%20antioxidant%20enzymes%20and%20various%20senescence-associated%20secretory%20phenotypes%20%28SASP%29%20as%20well%20as%20a%20decrease%20in%20histone%20proteins.%20Such%20protein%20expression%20patterns%20are%20potentially%20indicative%20of%20placental%20senescence.%20Our%20findings%20reveal%20that%20depression%20not%20treated%20with%20SRIs%20is%20associated%20with%20the%20upregulation%20of%20proteins%20involved%20in%20platelet%20activation%2C%20degranulation%2C%20coagulation%20cascade%2C%20and%20amyloid%20fiber%20formation%20in%20the%20placenta.%20In%20contrast%2C%20when%20comparing%20placentas%20from%20the%20depressed%20group%20treated%20with%20SRIs%20to%20those%20with%20depressive%20symptoms%20without%20SRI%20treatment%2C%20we%20observed%20a%20downregulation%20of%20proteins%20related%20to%20senescence%2C%20amyloid%20fiber%20formation%2C%20and%20platelet%20activation%20in%20the%20SRI-treated%20group.%20This%20study%20suggests%20that%20treatment%20with%20SRIs%20may%20prevent%20the%20placental%20alterations%20observed%20in%20antenatal%20depression%2C%20such%20as%20placental%20senescence%2C%20platelet%20activation%2C%20and%20amyloid%20fiber%20formation%2C%20and%2C%20ultimately%2C%20pregnancy%20and%20fetal%20outcomes.%20Further%20studies%20are%20needed%20to%20confirm%20these%20findings.%22%2C%22date%22%3A%222025-12-11%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0322090%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pone.0322090%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221932-6203%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%227XLZYQH9%22%5D%2C%22dateModified%22%3A%222026-04-13T15%3A20%3A25Z%22%7D%7D%2C%7B%22key%22%3A%22BT3QKD2V%22%2C%22library%22%3A%7B%22id%22%3A8435569%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ok%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BOk%2C%20Linda%2C%20Leanne%20Ohlund%2C%20Amy%20M.%20Inkster%2C%20et%20al.%202025.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pone.0322090%26%23039%3B%26gt%3BEffect%20of%20depression%20and%20serotonin%20reuptake%20inhibitors%20antidepressant%20treatment%20during%20pregnancy%20on%20protein%20expression%20in%20the%20human%20placenta%3A%20A%20quantitative%20proteomics%20analysis%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BPLOS%20One%26lt%3B%5C%2Fi%26gt%3B%2020%20%2812%29%3A%20e0322090.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0322090.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D8435569%26amp%3Bdlkey%3DG269K3PT%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20depression%20and%20serotonin%20reuptake%20inhibitors%20antidepressant%20treatment%20during%20pregnancy%20on%20protein%20expression%20in%20the%20human%20placenta%3A%20A%20quantitative%20proteomics%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Ok%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leanne%22%2C%22lastName%22%3A%22Ohlund%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%20M.%22%2C%22lastName%22%3A%22Inkster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kayleigh%20S.%20J.%22%2C%22lastName%22%3A%22Campbell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20S.%22%2C%22lastName%22%3A%22Pe%5Cu00f1aherrera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ursula%22%2C%22lastName%22%3A%22Brain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lekha%22%2C%22lastName%22%3A%22Sleno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wendy%20P.%22%2C%22lastName%22%3A%22Robinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amadou%22%2C%22lastName%22%3A%22Barry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tim%20F.%22%2C%22lastName%22%3A%22Oberlander%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathy%22%2C%22lastName%22%3A%22Vaillancourt%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Ayman%20A%22%2C%22lastName%22%3A%22Swelum%22%7D%5D%2C%22abstractNote%22%3A%22Depression%20is%20one%20of%20the%20most%20prevalent%20mental%20health%20disorders%20affecting%20pregnant%20individuals%2C%20and%20serotonin%20reuptake%20inhibitors%20%28SRIs%29%20are%20the%20most%20prescribed%20medications%20to%20treat%20depressive%20symptoms%20during%20pregnancy.%20Both%20depression%20and%20SRI%20exposure%20may%20have%20developmental%20impacts%2C%20and%20as%20randomizing%20exposures%20and%20non-treatment%20is%20not%20feasible%20in%20humans%2C%20distinguishing%20the%20effect%20of%20each%20factor%20often%20remains%20challenging.%20To%20date%2C%20much%20of%20what%20guides%20clinical%20practice%20stems%20from%20reports%20of%20pregnant%20individuals%20and%20fetal%5C%2Finfant%20outcomes%2C%20overlooking%20the%20significant%20role%20of%20the%20placenta%20in%20maintaining%20a%20healthy%20pregnancy%20and%20mother-fetal%20health.%20In%20this%20study%2C%20we%20explored%20the%20effect%20of%20depression%20and%20SRI%20antidepressant%20treatment%20during%20pregnancy%20on%20the%20placental%20proteome.%20A%20shotgun%20proteomics%20method%20with%20liquid%20chromatography%20and%20tandem%20mass%20spectrometry%20%28LC-MS%5C%2FMS%29%20was%20performed.%20A%20cohort%20of%20pregnant%20individuals%20%28n%5Cu2009%3D%5Cu200982%29%20was%20recruited%20in%20their%202%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20nd%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20trimester%2C%20and%20clinician-rated%20mood%20symptoms%20measured%20using%20the%20Hamilton%20Depression%20Rating%20Scale%20%28HAM-D%29%20were%20obtained%20from%20them%20during%20pregnancy%20to%20identify%20three%20exposure%20groups%3A%20non-depressed%3B%20depressed%5C%2Fnon-SRI-treated%3B%20depressed%5C%2FSRI-treated.%20Differential%20protein%20expression%20and%20over-representation%20analyses%20on%20the%20placentas%20of%20the%20group%20with%20depression%5C%2Fnon-SRI%20compared%20with%20placentas%20from%20healthy%20individuals%20showed%20an%20increase%20in%20antioxidant%20enzymes%20and%20various%20senescence-associated%20secretory%20phenotypes%20%28SASP%29%20as%20well%20as%20a%20decrease%20in%20histone%20proteins.%20Such%20protein%20expression%20patterns%20are%20potentially%20indicative%20of%20placental%20senescence.%20Our%20findings%20reveal%20that%20depression%20not%20treated%20with%20SRIs%20is%20associated%20with%20the%20upregulation%20of%20proteins%20involved%20in%20platelet%20activation%2C%20degranulation%2C%20coagulation%20cascade%2C%20and%20amyloid%20fiber%20formation%20in%20the%20placenta.%20In%20contrast%2C%20when%20comparing%20placentas%20from%20the%20depressed%20group%20treated%20with%20SRIs%20to%20those%20with%20depressive%20symptoms%20without%20SRI%20treatment%2C%20we%20observed%20a%20downregulation%20of%20proteins%20related%20to%20senescence%2C%20amyloid%20fiber%20formation%2C%20and%20platelet%20activation%20in%20the%20SRI-treated%20group.%20This%20study%20suggests%20that%20treatment%20with%20SRIs%20may%20prevent%20the%20placental%20alterations%20observed%20in%20antenatal%20depression%2C%20such%20as%20placental%20senescence%2C%20platelet%20activation%2C%20and%20amyloid%20fiber%20formation%2C%20and%2C%20ultimately%2C%20pregnancy%20and%20fetal%20outcomes.%20Further%20studies%20are%20needed%20to%20confirm%20these%20findings.%22%2C%22date%22%3A%222025-12-11%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0322090%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pone.0322090%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221932-6203%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-04-13T15%3A19%3A06Z%22%7D%7D%2C%7B%22key%22%3A%22FVEEMFI7%22%2C%22library%22%3A%7B%22id%22%3A8435569%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ok%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BOk%2C%20Linda%2C%20Leanne%20Ohlund%2C%20Amy%20M.%20Inkster%2C%20et%20al.%202025.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pone.0322090%26%23039%3B%26gt%3BEffect%20of%20depression%20and%20serotonin%20reuptake%20inhibitors%20antidepressant%20treatment%20during%20pregnancy%20on%20protein%20expression%20in%20the%20human%20placenta%3A%20A%20quantitative%20proteomics%20analysis%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BPLOS%20One%26lt%3B%5C%2Fi%26gt%3B%2020%20%2812%29%3A%20e0322090.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0322090.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D8435569%26amp%3Bdlkey%3DDX9QFMNT%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Effect%20of%20depression%20and%20serotonin%20reuptake%20inhibitors%20antidepressant%20treatment%20during%20pregnancy%20on%20protein%20expression%20in%20the%20human%20placenta%3A%20A%20quantitative%20proteomics%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Ok%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leanne%22%2C%22lastName%22%3A%22Ohlund%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amy%20M.%22%2C%22lastName%22%3A%22Inkster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kayleigh%20S.%20J.%22%2C%22lastName%22%3A%22Campbell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20S.%22%2C%22lastName%22%3A%22Pe%5Cu00f1aherrera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ursula%22%2C%22lastName%22%3A%22Brain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lekha%22%2C%22lastName%22%3A%22Sleno%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wendy%20P.%22%2C%22lastName%22%3A%22Robinson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Amadou%22%2C%22lastName%22%3A%22Barry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tim%20F.%22%2C%22lastName%22%3A%22Oberlander%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathy%22%2C%22lastName%22%3A%22Vaillancourt%22%7D%2C%7B%22creatorType%22%3A%22editor%22%2C%22firstName%22%3A%22Ayman%20A%22%2C%22lastName%22%3A%22Swelum%22%7D%5D%2C%22abstractNote%22%3A%22Depression%20is%20one%20of%20the%20most%20prevalent%20mental%20health%20disorders%20affecting%20pregnant%20individuals%2C%20and%20serotonin%20reuptake%20inhibitors%20%28SRIs%29%20are%20the%20most%20prescribed%20medications%20to%20treat%20depressive%20symptoms%20during%20pregnancy.%20Both%20depression%20and%20SRI%20exposure%20may%20have%20developmental%20impacts%2C%20and%20as%20randomizing%20exposures%20and%20non-treatment%20is%20not%20feasible%20in%20humans%2C%20distinguishing%20the%20effect%20of%20each%20factor%20often%20remains%20challenging.%20To%20date%2C%20much%20of%20what%20guides%20clinical%20practice%20stems%20from%20reports%20of%20pregnant%20individuals%20and%20fetal%5C%2Finfant%20outcomes%2C%20overlooking%20the%20significant%20role%20of%20the%20placenta%20in%20maintaining%20a%20healthy%20pregnancy%20and%20mother-fetal%20health.%20In%20this%20study%2C%20we%20explored%20the%20effect%20of%20depression%20and%20SRI%20antidepressant%20treatment%20during%20pregnancy%20on%20the%20placental%20proteome.%20A%20shotgun%20proteomics%20method%20with%20liquid%20chromatography%20and%20tandem%20mass%20spectrometry%20%28LC-MS%5C%2FMS%29%20was%20performed.%20A%20cohort%20of%20pregnant%20individuals%20%28n%5Cu2009%3D%5Cu200982%29%20was%20recruited%20in%20their%202%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20nd%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20trimester%2C%20and%20clinician-rated%20mood%20symptoms%20measured%20using%20the%20Hamilton%20Depression%20Rating%20Scale%20%28HAM-D%29%20were%20obtained%20from%20them%20during%20pregnancy%20to%20identify%20three%20exposure%20groups%3A%20non-depressed%3B%20depressed%5C%2Fnon-SRI-treated%3B%20depressed%5C%2FSRI-treated.%20Differential%20protein%20expression%20and%20over-representation%20analyses%20on%20the%20placentas%20of%20the%20group%20with%20depression%5C%2Fnon-SRI%20compared%20with%20placentas%20from%20healthy%20individuals%20showed%20an%20increase%20in%20antioxidant%20enzymes%20and%20various%20senescence-associated%20secretory%20phenotypes%20%28SASP%29%20as%20well%20as%20a%20decrease%20in%20histone%20proteins.%20Such%20protein%20expression%20patterns%20are%20potentially%20indicative%20of%20placental%20senescence.%20Our%20findings%20reveal%20that%20depression%20not%20treated%20with%20SRIs%20is%20associated%20with%20the%20upregulation%20of%20proteins%20involved%20in%20platelet%20activation%2C%20degranulation%2C%20coagulation%20cascade%2C%20and%20amyloid%20fiber%20formation%20in%20the%20placenta.%20In%20contrast%2C%20when%20comparing%20placentas%20from%20the%20depressed%20group%20treated%20with%20SRIs%20to%20those%20with%20depressive%20symptoms%20without%20SRI%20treatment%2C%20we%20observed%20a%20downregulation%20of%20proteins%20related%20to%20senescence%2C%20amyloid%20fiber%20formation%2C%20and%20platelet%20activation%20in%20the%20SRI-treated%20group.%20This%20study%20suggests%20that%20treatment%20with%20SRIs%20may%20prevent%20the%20placental%20alterations%20observed%20in%20antenatal%20depression%2C%20such%20as%20placental%20senescence%2C%20platelet%20activation%2C%20and%20amyloid%20fiber%20formation%2C%20and%2C%20ultimately%2C%20pregnancy%20and%20fetal%20outcomes.%20Further%20studies%20are%20needed%20to%20confirm%20these%20findings.%22%2C%22date%22%3A%222025-12-11%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0322090%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdx.plos.org%5C%2F10.1371%5C%2Fjournal.pone.0322090%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221932-6203%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-04-13T15%3A19%3A04Z%22%7D%7D%2C%7B%22key%22%3A%22EYSTEB75%22%2C%22library%22%3A%7B%22id%22%3A8435569%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lebourg%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLebourg%2C%20Aurore%2C%20Louis-Philippe%20Leroux%2C%20Visnu%20Chaparro%2C%20Sophie%20Chagneau%2C%20Cathy%20Vaillancourt%2C%20and%20Maritza%20Jaramillo.%202025.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffcimb.2025.1651142%5C%2Ffull%26%23039%3B%26gt%3BToxoplasma%20gondii%20infection%20inhibits%20invasion%20and%20migration%20of%20human%20extravillous%20trophoblasts%20through%20dysregulation%20of%20FOXO1-%20and%20FOXO3a-dependent%20and%20-independent%20mechanisms%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BFrontiers%20in%20Cellular%20and%20Infection%20Microbiology%26lt%3B%5C%2Fi%26gt%3B%2015%20%28December%29%3A%201651142.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffcimb.2025.1651142.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D8435569%26amp%3Bdlkey%3DE9TD25NM%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Toxoplasma%20gondii%20infection%20inhibits%20invasion%20and%20migration%20of%20human%20extravillous%20trophoblasts%20through%20dysregulation%20of%20FOXO1-%20and%20FOXO3a-dependent%20and%20-independent%20mechanisms%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurore%22%2C%22lastName%22%3A%22Lebourg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis-Philippe%22%2C%22lastName%22%3A%22Leroux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Visnu%22%2C%22lastName%22%3A%22Chaparro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Chagneau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathy%22%2C%22lastName%22%3A%22Vaillancourt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maritza%22%2C%22lastName%22%3A%22Jaramillo%22%7D%5D%2C%22abstractNote%22%3A%22The%20protozoan%20parasite%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Toxoplasma%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20causes%20severe%20pathologies%20in%20the%20infected%20fetus%20following%20vertical%20transmission%20during%20pregnancy.%20Primary%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20infection%20increases%20the%20risk%20of%20miscarriage%20during%20the%20first%20trimester%20of%20gestation%3B%20however%2C%20the%20cellular%20and%20molecular%20mechanisms%20are%20not%20fully%20understood.%20Extravillous%20trophoblasts%20%28EVTs%29%20are%20fetal%20cells%20that%20migrate%20and%20invade%20the%20maternal%20decidua%20to%20allow%20placenta%20formation%20and%20embryo%20implantation.%20The%20transcription%20factors%20Forkhead%20box%20O3a%20%28FOXO3a%29%20and%20FOXO1%20play%20a%20central%20role%20in%20the%20regulation%20of%20EVT%20migration%20and%20invasion.%20Hence%2C%20impairment%20of%20EVT%20functions%20is%20associated%20with%20FOXO3a%5C%2FFOXO1%20dysregulation%20and%20poor%20pregnancy%20outcomes.%20Interestingly%2C%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20-driven%20inactivation%20of%20FOXO3a%20and%20FOXO1%20was%20reported%20in%20fibroblasts%20and%20macrophages.%20Using%20a%20combination%20of%20cell%20imaging%2C%20reverse%20genetics%20and%20biochemical%20approaches%20in%20the%20human%20trophoblast%20cell%20line%20HTR-8%5C%2FSVneo%2C%20herein%20we%20provide%20evidence%20that%20infection%20with%20type%20I%20RH%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20strain%20inhibits%20invasiveness%20and%20migratory%20activities%20in%20EVTs%20by%20repressing%20FOXO3a-and%20FOXO1-dependent%20and%20independent%20gene%20expression.%20Indeed%2C%20either%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20infection%20or%20single%20knockdown%20of%20FOXO3a%20and%20FOXO1%20reduced%20invasion%20and%20migration%20properties%20in%20EVTs.%20Selective%20chemical%20blockade%20of%20parasite%20motility%20and%20host%20cell%20entry%20indicates%20that%20active%20infection%20is%20indispensable%20for%20reduced%20EVT%20migration%20but%20is%20only%20partially%20required%20for%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20-driven%20repression%20of%20EVT%20invasiveness.%20Mechanistically%2C%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20infection%20led%20to%20AKT-sensitive%20phosphorylation%20and%20nuclear%20exclusion%20of%20FOXO3a%20and%20FOXO1%20in%20EVTs.%20An%20RT-qPCR-based%20screening%20identified%20a%20subset%20of%20invasion-and%20migration-associated%20genes%20downregulated%20in%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20-infected%20EVTs%20%28MMP2%2C%20MMP3%2C%20MMP14%2C%20TIMP2%2C%20MUC1%2C%20and%20ITGB3%29.%20Transcription%20of%20genes%20encoding%20MMP3%20and%20integrin%20%5Cu03b23%20decreased%20in%20FOXO3a%20KD%20and%20FOXO1%20KD%20EVT%20cell%20lines%2C%20respectively.%20These%20data%20along%20with%20pharmacological%20inhibition%20of%20AKT%20in%20infected%20cells%20provide%20evidence%20that%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20downregulates%20MMP3%20and%20ITGB3%20gene%20expression%20in%20EVTs%20in%20an%20AKT-FOXO3a%5C%2FFOXO1-dependent%20fashion.%20In%20all%2C%20we%20have%20uncovered%20a%20novel%20regulatory%20mechanism%20involved%20in%20the%20repression%20of%20EVT%20migration%20and%20invasion%20properties%20during%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20infection.%20Further%20investigation%20using%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20vivo%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20and%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20ex%20vivo%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20models%20of%20placental%20infection%20is%20required%20to%20determine%20whether%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20-driven%20dysregulation%20of%20EVT%20functions%20contributes%20to%20pregnancy%20complications%20associated%20with%20congenital%20toxoplasmosis.%22%2C%22date%22%3A%222025-12-10%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffcimb.2025.1651142%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffcimb.2025.1651142%5C%2Ffull%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222235-2988%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%227XLZYQH9%22%5D%2C%22dateModified%22%3A%222026-04-13T15%3A20%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22ZS9ZAHJM%22%2C%22library%22%3A%7B%22id%22%3A8435569%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lebourg%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLebourg%2C%20Aurore%2C%20Louis-Philippe%20Leroux%2C%20Visnu%20Chaparro%2C%20Sophie%20Chagneau%2C%20Cathy%20Vaillancourt%2C%20and%20Maritza%20Jaramillo.%202025.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffcimb.2025.1651142%5C%2Ffull%26%23039%3B%26gt%3BToxoplasma%20gondii%20infection%20inhibits%20invasion%20and%20migration%20of%20human%20extravillous%20trophoblasts%20through%20dysregulation%20of%20FOXO1-%20and%20FOXO3a-dependent%20and%20-independent%20mechanisms%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BFrontiers%20in%20Cellular%20and%20Infection%20Microbiology%26lt%3B%5C%2Fi%26gt%3B%2015%20%28December%29%3A%201651142.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffcimb.2025.1651142.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D8435569%26amp%3Bdlkey%3D9MVTZUKN%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Toxoplasma%20gondii%20infection%20inhibits%20invasion%20and%20migration%20of%20human%20extravillous%20trophoblasts%20through%20dysregulation%20of%20FOXO1-%20and%20FOXO3a-dependent%20and%20-independent%20mechanisms%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurore%22%2C%22lastName%22%3A%22Lebourg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis-Philippe%22%2C%22lastName%22%3A%22Leroux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Visnu%22%2C%22lastName%22%3A%22Chaparro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Chagneau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathy%22%2C%22lastName%22%3A%22Vaillancourt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maritza%22%2C%22lastName%22%3A%22Jaramillo%22%7D%5D%2C%22abstractNote%22%3A%22The%20protozoan%20parasite%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Toxoplasma%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20causes%20severe%20pathologies%20in%20the%20infected%20fetus%20following%20vertical%20transmission%20during%20pregnancy.%20Primary%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20infection%20increases%20the%20risk%20of%20miscarriage%20during%20the%20first%20trimester%20of%20gestation%3B%20however%2C%20the%20cellular%20and%20molecular%20mechanisms%20are%20not%20fully%20understood.%20Extravillous%20trophoblasts%20%28EVTs%29%20are%20fetal%20cells%20that%20migrate%20and%20invade%20the%20maternal%20decidua%20to%20allow%20placenta%20formation%20and%20embryo%20implantation.%20The%20transcription%20factors%20Forkhead%20box%20O3a%20%28FOXO3a%29%20and%20FOXO1%20play%20a%20central%20role%20in%20the%20regulation%20of%20EVT%20migration%20and%20invasion.%20Hence%2C%20impairment%20of%20EVT%20functions%20is%20associated%20with%20FOXO3a%5C%2FFOXO1%20dysregulation%20and%20poor%20pregnancy%20outcomes.%20Interestingly%2C%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20-driven%20inactivation%20of%20FOXO3a%20and%20FOXO1%20was%20reported%20in%20fibroblasts%20and%20macrophages.%20Using%20a%20combination%20of%20cell%20imaging%2C%20reverse%20genetics%20and%20biochemical%20approaches%20in%20the%20human%20trophoblast%20cell%20line%20HTR-8%5C%2FSVneo%2C%20herein%20we%20provide%20evidence%20that%20infection%20with%20type%20I%20RH%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20strain%20inhibits%20invasiveness%20and%20migratory%20activities%20in%20EVTs%20by%20repressing%20FOXO3a-and%20FOXO1-dependent%20and%20independent%20gene%20expression.%20Indeed%2C%20either%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20infection%20or%20single%20knockdown%20of%20FOXO3a%20and%20FOXO1%20reduced%20invasion%20and%20migration%20properties%20in%20EVTs.%20Selective%20chemical%20blockade%20of%20parasite%20motility%20and%20host%20cell%20entry%20indicates%20that%20active%20infection%20is%20indispensable%20for%20reduced%20EVT%20migration%20but%20is%20only%20partially%20required%20for%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20-driven%20repression%20of%20EVT%20invasiveness.%20Mechanistically%2C%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20infection%20led%20to%20AKT-sensitive%20phosphorylation%20and%20nuclear%20exclusion%20of%20FOXO3a%20and%20FOXO1%20in%20EVTs.%20An%20RT-qPCR-based%20screening%20identified%20a%20subset%20of%20invasion-and%20migration-associated%20genes%20downregulated%20in%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20-infected%20EVTs%20%28MMP2%2C%20MMP3%2C%20MMP14%2C%20TIMP2%2C%20MUC1%2C%20and%20ITGB3%29.%20Transcription%20of%20genes%20encoding%20MMP3%20and%20integrin%20%5Cu03b23%20decreased%20in%20FOXO3a%20KD%20and%20FOXO1%20KD%20EVT%20cell%20lines%2C%20respectively.%20These%20data%20along%20with%20pharmacological%20inhibition%20of%20AKT%20in%20infected%20cells%20provide%20evidence%20that%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20downregulates%20MMP3%20and%20ITGB3%20gene%20expression%20in%20EVTs%20in%20an%20AKT-FOXO3a%5C%2FFOXO1-dependent%20fashion.%20In%20all%2C%20we%20have%20uncovered%20a%20novel%20regulatory%20mechanism%20involved%20in%20the%20repression%20of%20EVT%20migration%20and%20invasion%20properties%20during%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20infection.%20Further%20investigation%20using%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20vivo%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20and%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20ex%20vivo%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20models%20of%20placental%20infection%20is%20required%20to%20determine%20whether%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20-driven%20dysregulation%20of%20EVT%20functions%20contributes%20to%20pregnancy%20complications%20associated%20with%20congenital%20toxoplasmosis.%22%2C%22date%22%3A%222025-12-10%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffcimb.2025.1651142%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffcimb.2025.1651142%5C%2Ffull%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222235-2988%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-04-13T15%3A20%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22DH8X2DUQ%22%2C%22library%22%3A%7B%22id%22%3A8435569%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lebourg%20et%20al.%22%2C%22parsedDate%22%3A%222025-12-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLebourg%2C%20Aurore%2C%20Louis-Philippe%20Leroux%2C%20Visnu%20Chaparro%2C%20Sophie%20Chagneau%2C%20Cathy%20Vaillancourt%2C%20and%20Maritza%20Jaramillo.%202025.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffcimb.2025.1651142%5C%2Ffull%26%23039%3B%26gt%3BToxoplasma%20gondii%20infection%20inhibits%20invasion%20and%20migration%20of%20human%20extravillous%20trophoblasts%20through%20dysregulation%20of%20FOXO1-%20and%20FOXO3a-dependent%20and%20-independent%20mechanisms%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BFrontiers%20in%20Cellular%20and%20Infection%20Microbiology%26lt%3B%5C%2Fi%26gt%3B%2015%20%28December%29%3A%201651142.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffcimb.2025.1651142.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D8435569%26amp%3Bdlkey%3DTSZ532YY%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Toxoplasma%20gondii%20infection%20inhibits%20invasion%20and%20migration%20of%20human%20extravillous%20trophoblasts%20through%20dysregulation%20of%20FOXO1-%20and%20FOXO3a-dependent%20and%20-independent%20mechanisms%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aurore%22%2C%22lastName%22%3A%22Lebourg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louis-Philippe%22%2C%22lastName%22%3A%22Leroux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Visnu%22%2C%22lastName%22%3A%22Chaparro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Chagneau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathy%22%2C%22lastName%22%3A%22Vaillancourt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maritza%22%2C%22lastName%22%3A%22Jaramillo%22%7D%5D%2C%22abstractNote%22%3A%22The%20protozoan%20parasite%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Toxoplasma%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20causes%20severe%20pathologies%20in%20the%20infected%20fetus%20following%20vertical%20transmission%20during%20pregnancy.%20Primary%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20infection%20increases%20the%20risk%20of%20miscarriage%20during%20the%20first%20trimester%20of%20gestation%3B%20however%2C%20the%20cellular%20and%20molecular%20mechanisms%20are%20not%20fully%20understood.%20Extravillous%20trophoblasts%20%28EVTs%29%20are%20fetal%20cells%20that%20migrate%20and%20invade%20the%20maternal%20decidua%20to%20allow%20placenta%20formation%20and%20embryo%20implantation.%20The%20transcription%20factors%20Forkhead%20box%20O3a%20%28FOXO3a%29%20and%20FOXO1%20play%20a%20central%20role%20in%20the%20regulation%20of%20EVT%20migration%20and%20invasion.%20Hence%2C%20impairment%20of%20EVT%20functions%20is%20associated%20with%20FOXO3a%5C%2FFOXO1%20dysregulation%20and%20poor%20pregnancy%20outcomes.%20Interestingly%2C%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20-driven%20inactivation%20of%20FOXO3a%20and%20FOXO1%20was%20reported%20in%20fibroblasts%20and%20macrophages.%20Using%20a%20combination%20of%20cell%20imaging%2C%20reverse%20genetics%20and%20biochemical%20approaches%20in%20the%20human%20trophoblast%20cell%20line%20HTR-8%5C%2FSVneo%2C%20herein%20we%20provide%20evidence%20that%20infection%20with%20type%20I%20RH%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20strain%20inhibits%20invasiveness%20and%20migratory%20activities%20in%20EVTs%20by%20repressing%20FOXO3a-and%20FOXO1-dependent%20and%20independent%20gene%20expression.%20Indeed%2C%20either%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20infection%20or%20single%20knockdown%20of%20FOXO3a%20and%20FOXO1%20reduced%20invasion%20and%20migration%20properties%20in%20EVTs.%20Selective%20chemical%20blockade%20of%20parasite%20motility%20and%20host%20cell%20entry%20indicates%20that%20active%20infection%20is%20indispensable%20for%20reduced%20EVT%20migration%20but%20is%20only%20partially%20required%20for%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20-driven%20repression%20of%20EVT%20invasiveness.%20Mechanistically%2C%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20infection%20led%20to%20AKT-sensitive%20phosphorylation%20and%20nuclear%20exclusion%20of%20FOXO3a%20and%20FOXO1%20in%20EVTs.%20An%20RT-qPCR-based%20screening%20identified%20a%20subset%20of%20invasion-and%20migration-associated%20genes%20downregulated%20in%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20-infected%20EVTs%20%28MMP2%2C%20MMP3%2C%20MMP14%2C%20TIMP2%2C%20MUC1%2C%20and%20ITGB3%29.%20Transcription%20of%20genes%20encoding%20MMP3%20and%20integrin%20%5Cu03b23%20decreased%20in%20FOXO3a%20KD%20and%20FOXO1%20KD%20EVT%20cell%20lines%2C%20respectively.%20These%20data%20along%20with%20pharmacological%20inhibition%20of%20AKT%20in%20infected%20cells%20provide%20evidence%20that%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20downregulates%20MMP3%20and%20ITGB3%20gene%20expression%20in%20EVTs%20in%20an%20AKT-FOXO3a%5C%2FFOXO1-dependent%20fashion.%20In%20all%2C%20we%20have%20uncovered%20a%20novel%20regulatory%20mechanism%20involved%20in%20the%20repression%20of%20EVT%20migration%20and%20invasion%20properties%20during%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20infection.%20Further%20investigation%20using%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20in%20vivo%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20and%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20ex%20vivo%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20models%20of%20placental%20infection%20is%20required%20to%20determine%20whether%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20T.%20gondii%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20-driven%20dysregulation%20of%20EVT%20functions%20contributes%20to%20pregnancy%20complications%20associated%20with%20congenital%20toxoplasmosis.%22%2C%22date%22%3A%222025-12-10%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffcimb.2025.1651142%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffcimb.2025.1651142%5C%2Ffull%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222235-2988%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-04-13T15%3A19%3A58Z%22%7D%7D%2C%7B%22key%22%3A%22IK94LSSH%22%2C%22library%22%3A%7B%22id%22%3A8435569%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brun%20et%20al.%22%2C%22parsedDate%22%3A%222025-10-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBrun%2C%20Ang%5Cu00e9lique%2C%20Stephanie-May%20Ruchat%2C%20Sophie%20Chaput-Langlois%2C%20et%20al.%202025.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F1660-4601%5C%2F22%5C%2F10%5C%2F1538%26%23039%3B%26gt%3BAssociations%20Between%20Walking%20in%20the%20Third%20Trimester%20of%20Pregnancy%20and%20Maternal%20Mental%20Health%20During%20the%20COVID-19%20Pandemic%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BInternational%20Journal%20of%20Environmental%20Research%20and%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2022%20%2810%29%3A%201538.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fijerph22101538.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D8435569%26amp%3Bdlkey%3DUIF8EHJA%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Associations%20Between%20Walking%20in%20the%20Third%20Trimester%20of%20Pregnancy%20and%20Maternal%20Mental%20Health%20During%20the%20COVID-19%20Pandemic%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ang%5Cu00e9lique%22%2C%22lastName%22%3A%22Brun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie-May%22%2C%22lastName%22%3A%22Ruchat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Chaput-Langlois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Booij%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rapha%5Cu00eblle%22%2C%22lastName%22%3A%22Giac%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katherine%22%2C%22lastName%22%3A%22S%5Cu00e9guin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9anne%22%2C%22lastName%22%3A%22Bernier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Sophie%22%2C%22lastName%22%3A%22Morisset%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Boucoiran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathy%22%2C%22lastName%22%3A%22Vaillancourt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Lipp%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%20M.%22%2C%22lastName%22%3A%22Herba%22%7D%5D%2C%22abstractNote%22%3A%22Prenatal%20physical%20activity%20%28PA%29%20has%20well-established%20benefits%20for%20maternal%20mental%20health.%20However%2C%20PA%20levels%20are%20generally%20low%20among%20pregnant%20individuals%20and%20were%20even%20lower%20during%20the%20COVID-19%20pandemic.%20Since%20walking%20is%20the%20most%20popular%20form%20of%20prenatal%20PA%2C%20we%20aimed%20to%20examine%20associations%20between%20walking%20in%20the%20third%20trimester%20of%20pregnancy%20and%20mental%20health%20symptoms%20of%20depression%2C%20anxiety%2C%20pregnancy-related%20anxiety%20and%20perceived%20stress%20during%20the%20pandemic.%20Relevant%20pandemic-related%20factors%20%28e.g.%2C%20COVID-19%20waves%2C%20population%20density%29%20associated%20with%20walking%20were%20also%20studied.%20Pregnant%20individuals%20were%20recruited%20across%20Quebec%20%28Canada%29%20between%20October%202020%20and%20September%202022%2C%20as%20part%20of%20the%20Resilience%20and%20Perinatal%20Stress%20during%20the%20Pandemic%20%28RESPPA%29%20study.%20Analyses%20were%20conducted%20on%20data%20collected%20via%20online%20questionnaires%20during%20the%20third%20trimester%20%28n%20%3D%201086%29.%20Results%20revealed%20that%20higher%20levels%20of%20walking%20were%20significantly%20associated%20with%20lower%20symptoms%20of%20generalized%20anxiety%20%28%5Cu03b2%20%3D%20%5Cu22120.06%2C%20p%20%3D%200.035%29%2C%20and%20perceived%20stress%20%28%5Cu03b2%20%3D%20%5Cu22120.07%2C%20p%20%3D%200.007%29.%20Living%20in%20a%20more%20densely%20populated%20area%2C%20living%20with%20fewer%20children%20at%20home%20and%20having%20a%20university%20degree%20were%20associated%20with%20higher%20levels%20of%20walking.%20Those%20who%20completed%20their%20questionnaire%20in%20the%20second%20pandemic%20wave%20also%20reported%20higher%20levels%20of%20walking.%20Our%20results%20highlight%20the%20potential%20of%20walking%20in%20the%20third%20trimester%20to%20support%20maternal%20mental%20health.%22%2C%22date%22%3A%222025-10-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3390%5C%2Fijerph22101538%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F1660-4601%5C%2F22%5C%2F10%5C%2F1538%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221660-4601%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-04-13T15%3A32%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22YS6M962L%22%2C%22library%22%3A%7B%22id%22%3A8435569%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brun%20et%20al.%22%2C%22parsedDate%22%3A%222025-10-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBrun%2C%20Ang%5Cu00e9lique%2C%20Stephanie-May%20Ruchat%2C%20Sophie%20Chaput-Langlois%2C%20et%20al.%202025.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F1660-4601%5C%2F22%5C%2F10%5C%2F1538%26%23039%3B%26gt%3BAssociations%20Between%20Walking%20in%20the%20Third%20Trimester%20of%20Pregnancy%20and%20Maternal%20Mental%20Health%20During%20the%20COVID-19%20Pandemic%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BInternational%20Journal%20of%20Environmental%20Research%20and%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2022%20%2810%29%3A%201538.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fijerph22101538.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D8435569%26amp%3Bdlkey%3D2XYCLZM5%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Associations%20Between%20Walking%20in%20the%20Third%20Trimester%20of%20Pregnancy%20and%20Maternal%20Mental%20Health%20During%20the%20COVID-19%20Pandemic%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ang%5Cu00e9lique%22%2C%22lastName%22%3A%22Brun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie-May%22%2C%22lastName%22%3A%22Ruchat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Chaput-Langlois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Booij%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rapha%5Cu00eblle%22%2C%22lastName%22%3A%22Giac%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katherine%22%2C%22lastName%22%3A%22S%5Cu00e9guin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9anne%22%2C%22lastName%22%3A%22Bernier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Sophie%22%2C%22lastName%22%3A%22Morisset%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Boucoiran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathy%22%2C%22lastName%22%3A%22Vaillancourt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Lipp%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%20M.%22%2C%22lastName%22%3A%22Herba%22%7D%5D%2C%22abstractNote%22%3A%22Prenatal%20physical%20activity%20%28PA%29%20has%20well-established%20benefits%20for%20maternal%20mental%20health.%20However%2C%20PA%20levels%20are%20generally%20low%20among%20pregnant%20individuals%20and%20were%20even%20lower%20during%20the%20COVID-19%20pandemic.%20Since%20walking%20is%20the%20most%20popular%20form%20of%20prenatal%20PA%2C%20we%20aimed%20to%20examine%20associations%20between%20walking%20in%20the%20third%20trimester%20of%20pregnancy%20and%20mental%20health%20symptoms%20of%20depression%2C%20anxiety%2C%20pregnancy-related%20anxiety%20and%20perceived%20stress%20during%20the%20pandemic.%20Relevant%20pandemic-related%20factors%20%28e.g.%2C%20COVID-19%20waves%2C%20population%20density%29%20associated%20with%20walking%20were%20also%20studied.%20Pregnant%20individuals%20were%20recruited%20across%20Quebec%20%28Canada%29%20between%20October%202020%20and%20September%202022%2C%20as%20part%20of%20the%20Resilience%20and%20Perinatal%20Stress%20during%20the%20Pandemic%20%28RESPPA%29%20study.%20Analyses%20were%20conducted%20on%20data%20collected%20via%20online%20questionnaires%20during%20the%20third%20trimester%20%28n%20%3D%201086%29.%20Results%20revealed%20that%20higher%20levels%20of%20walking%20were%20significantly%20associated%20with%20lower%20symptoms%20of%20generalized%20anxiety%20%28%5Cu03b2%20%3D%20%5Cu22120.06%2C%20p%20%3D%200.035%29%2C%20and%20perceived%20stress%20%28%5Cu03b2%20%3D%20%5Cu22120.07%2C%20p%20%3D%200.007%29.%20Living%20in%20a%20more%20densely%20populated%20area%2C%20living%20with%20fewer%20children%20at%20home%20and%20having%20a%20university%20degree%20were%20associated%20with%20higher%20levels%20of%20walking.%20Those%20who%20completed%20their%20questionnaire%20in%20the%20second%20pandemic%20wave%20also%20reported%20higher%20levels%20of%20walking.%20Our%20results%20highlight%20the%20potential%20of%20walking%20in%20the%20third%20trimester%20to%20support%20maternal%20mental%20health.%22%2C%22date%22%3A%222025-10-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3390%5C%2Fijerph22101538%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F1660-4601%5C%2F22%5C%2F10%5C%2F1538%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221660-4601%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%227XLZYQH9%22%5D%2C%22dateModified%22%3A%222026-04-13T15%3A32%3A24Z%22%7D%7D%2C%7B%22key%22%3A%223398NVSY%22%2C%22library%22%3A%7B%22id%22%3A8435569%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Brun%20et%20al.%22%2C%22parsedDate%22%3A%222025-10-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBrun%2C%20Ang%5Cu00e9lique%2C%20Stephanie-May%20Ruchat%2C%20Sophie%20Chaput-Langlois%2C%20et%20al.%202025.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F1660-4601%5C%2F22%5C%2F10%5C%2F1538%26%23039%3B%26gt%3BAssociations%20Between%20Walking%20in%20the%20Third%20Trimester%20of%20Pregnancy%20and%20Maternal%20Mental%20Health%20During%20the%20COVID-19%20Pandemic%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BInternational%20Journal%20of%20Environmental%20Research%20and%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2022%20%2810%29%3A%201538.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fijerph22101538.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D8435569%26amp%3Bdlkey%3D6Z49KMSA%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Associations%20Between%20Walking%20in%20the%20Third%20Trimester%20of%20Pregnancy%20and%20Maternal%20Mental%20Health%20During%20the%20COVID-19%20Pandemic%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ang%5Cu00e9lique%22%2C%22lastName%22%3A%22Brun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephanie-May%22%2C%22lastName%22%3A%22Ruchat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sophie%22%2C%22lastName%22%3A%22Chaput-Langlois%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Linda%22%2C%22lastName%22%3A%22Booij%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rapha%5Cu00eblle%22%2C%22lastName%22%3A%22Giac%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katherine%22%2C%22lastName%22%3A%22S%5Cu00e9guin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andr%5Cu00e9anne%22%2C%22lastName%22%3A%22Bernier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Sophie%22%2C%22lastName%22%3A%22Morisset%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Boucoiran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathy%22%2C%22lastName%22%3A%22Vaillancourt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sarah%22%2C%22lastName%22%3A%22Lipp%5Cu00e9%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%20M.%22%2C%22lastName%22%3A%22Herba%22%7D%5D%2C%22abstractNote%22%3A%22Prenatal%20physical%20activity%20%28PA%29%20has%20well-established%20benefits%20for%20maternal%20mental%20health.%20However%2C%20PA%20levels%20are%20generally%20low%20among%20pregnant%20individuals%20and%20were%20even%20lower%20during%20the%20COVID-19%20pandemic.%20Since%20walking%20is%20the%20most%20popular%20form%20of%20prenatal%20PA%2C%20we%20aimed%20to%20examine%20associations%20between%20walking%20in%20the%20third%20trimester%20of%20pregnancy%20and%20mental%20health%20symptoms%20of%20depression%2C%20anxiety%2C%20pregnancy-related%20anxiety%20and%20perceived%20stress%20during%20the%20pandemic.%20Relevant%20pandemic-related%20factors%20%28e.g.%2C%20COVID-19%20waves%2C%20population%20density%29%20associated%20with%20walking%20were%20also%20studied.%20Pregnant%20individuals%20were%20recruited%20across%20Quebec%20%28Canada%29%20between%20October%202020%20and%20September%202022%2C%20as%20part%20of%20the%20Resilience%20and%20Perinatal%20Stress%20during%20the%20Pandemic%20%28RESPPA%29%20study.%20Analyses%20were%20conducted%20on%20data%20collected%20via%20online%20questionnaires%20during%20the%20third%20trimester%20%28n%20%3D%201086%29.%20Results%20revealed%20that%20higher%20levels%20of%20walking%20were%20significantly%20associated%20with%20lower%20symptoms%20of%20generalized%20anxiety%20%28%5Cu03b2%20%3D%20%5Cu22120.06%2C%20p%20%3D%200.035%29%2C%20and%20perceived%20stress%20%28%5Cu03b2%20%3D%20%5Cu22120.07%2C%20p%20%3D%200.007%29.%20Living%20in%20a%20more%20densely%20populated%20area%2C%20living%20with%20fewer%20children%20at%20home%20and%20having%20a%20university%20degree%20were%20associated%20with%20higher%20levels%20of%20walking.%20Those%20who%20completed%20their%20questionnaire%20in%20the%20second%20pandemic%20wave%20also%20reported%20higher%20levels%20of%20walking.%20Our%20results%20highlight%20the%20potential%20of%20walking%20in%20the%20third%20trimester%20to%20support%20maternal%20mental%20health.%22%2C%22date%22%3A%222025-10-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3390%5C%2Fijerph22101538%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F1660-4601%5C%2F22%5C%2F10%5C%2F1538%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221660-4601%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222026-04-13T15%3A32%3A23Z%22%7D%7D%2C%7B%22key%22%3A%2298GPY2ZY%22%2C%22library%22%3A%7B%22id%22%3A8435569%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Khiat%20et%20al.%22%2C%22parsedDate%22%3A%222025-01-03%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKhiat%2C%20Nihad%2C%20Julie%20Girouard%2C%20Emmanuelle%20Stella%20Kana%20Tsapi%2C%20Cathy%20Vaillancourt%2C%20C%5Cu00e9line%20Van%20Themsche%2C%20and%20Carlos%20Reyes-Moreno.%202025.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F2073-4409%5C%2F14%5C%2F1%5C%2F45%26%23039%3B%26gt%3BTGF%5Cu03b21%20Restores%20Energy%20Homeostasis%20of%20Human%20Trophoblast%20Cells%20Under%20Hyperglycemia%20In%20Vitro%20by%20Inducing%20PPAR%5Cu03b3%20Expression%2C%20AMPK%20Activation%2C%20and%20HIF1%5Cu03b1%20Degradation%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BCells%26lt%3B%5C%2Fi%26gt%3B%2014%20%281%29%3A%2045.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fcells14010045.%20%26lt%3Ba%20title%3D%26%23039%3BDownload%26%23039%3B%20class%3D%26%23039%3Bzp-DownloadURL%20zp-getDownloadURL%26%23039%3B%20data-zp-dl%3D%26%23039%3Bapi_user_id%3D8435569%26amp%3Bdlkey%3DM96NIIHZ%26amp%3Bcontent_type%3Dapplication%5C%2Fpdf%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BDownload%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22TGF%5Cu03b21%20Restores%20Energy%20Homeostasis%20of%20Human%20Trophoblast%20Cells%20Under%20Hyperglycemia%20In%20Vitro%20by%20Inducing%20PPAR%5Cu03b3%20Expression%2C%20AMPK%20Activation%2C%20and%20HIF1%5Cu03b1%20Degradation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nihad%22%2C%22lastName%22%3A%22Khiat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julie%22%2C%22lastName%22%3A%22Girouard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emmanuelle%20Stella%22%2C%22lastName%22%3A%22Kana%20Tsapi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathy%22%2C%22lastName%22%3A%22Vaillancourt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9line%22%2C%22lastName%22%3A%22Van%20Themsche%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carlos%22%2C%22lastName%22%3A%22Reyes-Moreno%22%7D%5D%2C%22abstractNote%22%3A%22Elevated%20glucose%20levels%20at%20the%20fetal%5Cu2013maternal%20interface%20are%20associated%20with%20placental%20trophoblast%20dysfunction%20and%20increased%20incidence%20of%20pregnancy%20complications.%20Trophoblast%20cells%20predominantly%20utilize%20glucose%20as%20an%20energy%20source%2C%20metabolizing%20it%20through%20glycolysis%20in%20the%20cytoplasm%20and%20oxidative%20respiration%20in%20the%20mitochondria%20to%20produce%20ATP.%20The%20TGF%5Cu03b21%5C%2FSMAD2%20signaling%20pathway%20and%20the%20transcription%20factors%20PPAR%5Cu03b3%2C%20HIF1%5Cu03b1%2C%20and%20AMPK%20are%20key%20regulators%20of%20cell%20metabolism%20and%20are%20known%20to%20play%20critical%20roles%20in%20extravillous%20trophoblast%20cell%20differentiation%20and%20function.%20While%20HIF1%5Cu03b1%20promotes%20glycolysis%20over%20mitochondrial%20respiration%2C%20PPAR%5Cu03b3%20and%20AMPK%20encourage%20the%20opposite.%20However%2C%20the%20interplay%20between%20TGF%5Cu03b21%20and%20these%20energy-sensing%20regulators%20in%20trophoblast%20cell%20glucose%20metabolism%20remains%20unclear.%20This%20study%20aimed%20to%20investigate%20whether%20and%20how%20TGF%5Cu03b21%20regulates%20energy%20metabolism%20in%20trophoblast%20cells%20exposed%20to%20normal%20and%20high%20glucose%20conditions.%20The%20trophoblast%20JEG-3%20cells%20were%20incubated%20in%20normal%20%285%20mM%29%20and%20high%20%2825%20mM%29%20glucose%20conditions%20for%2024%20h%20in%20the%20absence%20and%20the%20presence%20of%20TGF%5Cu03b21.%20The%20protein%20expression%20levels%20of%20phosphor%20%28p%29-SMAD2%2C%20GLUT1%5C%2F3%2C%20HIF1%5Cu03b1%2C%20PPAR%5Cu03b3%2C%20p-AMPK%2C%20and%20specific%20OXPHOS%20protein%20subunits%20were%20determined%20by%20western%20blotting%2C%20and%20ATP%20and%20lactate%20production%20by%20bioluminescent%20assay%20kits.%20JEG-3%20cells%20exposed%20to%2025%20mM%20glucose%20decreased%20ATP%20production%20but%20did%20not%20affect%20lactate%20production.%20These%20changes%20led%20to%20a%20reduction%20in%20the%20expression%20levels%20of%20GLUT1%5C%2F3%2C%20mitochondrial%20respiratory%20chain%20proteins%2C%20and%20PPAR%5Cu03b3%2C%20coinciding%20with%20an%20increase%20in%20HIF1%5Cu03b1%20expression.%20Conversely%2C%20TGF%5Cu03b21%20treatment%20at%2025%20mM%20glucose%20reduced%20HIF1%5Cu03b1%20expression%20while%20enhancing%20the%20expression%20levels%20of%20GLUT1%5C%2F3%2C%20PPAR%5Cu03b3%2C%20p-AMPK%2C%20and%20mitochondrial%20respiratory%20chain%20proteins%2C%20thereby%20rejuvenating%20ATP%20production.%20Our%20findings%20reveal%20that%20high%20glucose%20conditions%20disrupt%20cellular%20glucose%20metabolism%20in%20trophoblast%20cells%20by%20perturbing%20mitochondrial%20oxidative%20respiration%20and%20decreasing%20ATP%20production.%20Treatment%20with%20TGF%5Cu03b21%20appears%20to%20counteract%20this%20trend%2C%20probably%20by%20enhancing%20both%20glycolytic%20and%20mitochondrial%20metabolism%2C%20suggesting%20a%20potential%20regulatory%20role%20of%20TGF%5Cu03b21%20in%20placental%20trophoblast%20cell%20glucose%20metabolism.%22%2C%22date%22%3A%222025-01-03%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3390%5C%2Fcells14010045%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F2073-4409%5C%2F14%5C%2F1%5C%2F45%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222073-4409%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%227XLZYQH9%22%5D%2C%22dateModified%22%3A%222026-04-13T15%3A20%3A39Z%22%7D%7D%5D%7D
Lebourg, Aurore, Louis-Philippe Leroux, Visnu Chaparro, Sophie Chagneau, Cathy Vaillancourt, and Maritza Jaramillo. 2025. "
Toxoplasma gondii infection inhibits invasion and migration of human extravillous trophoblasts through dysregulation of FOXO1- and FOXO3a-dependent and -independent mechanisms."
Frontiers in Cellular and Infection Microbiology 15 (December): 1651142. https://doi.org/10.3389/fcimb.2025.1651142.
Download
Lebourg, Aurore, Louis-Philippe Leroux, Visnu Chaparro, Sophie Chagneau, Cathy Vaillancourt, and Maritza Jaramillo. 2025. "
Toxoplasma gondii infection inhibits invasion and migration of human extravillous trophoblasts through dysregulation of FOXO1- and FOXO3a-dependent and -independent mechanisms."
Frontiers in Cellular and Infection Microbiology 15 (December): 1651142. https://doi.org/10.3389/fcimb.2025.1651142.
Download
Lebourg, Aurore, Louis-Philippe Leroux, Visnu Chaparro, Sophie Chagneau, Cathy Vaillancourt, and Maritza Jaramillo. 2025. "
Toxoplasma gondii infection inhibits invasion and migration of human extravillous trophoblasts through dysregulation of FOXO1- and FOXO3a-dependent and -independent mechanisms."
Frontiers in Cellular and Infection Microbiology 15 (December): 1651142. https://doi.org/10.3389/fcimb.2025.1651142.
Download
Brun, Angélique, Stephanie-May Ruchat, Sophie Chaput-Langlois, et al. 2025. "
Associations Between Walking in the Third Trimester of Pregnancy and Maternal Mental Health During the COVID-19 Pandemic."
International Journal of Environmental Research and Public Health 22 (10): 1538. https://doi.org/10.3390/ijerph22101538.
Download
Brun, Angélique, Stephanie-May Ruchat, Sophie Chaput-Langlois, et al. 2025. "
Associations Between Walking in the Third Trimester of Pregnancy and Maternal Mental Health During the COVID-19 Pandemic."
International Journal of Environmental Research and Public Health 22 (10): 1538. https://doi.org/10.3390/ijerph22101538.
Download
Brun, Angélique, Stephanie-May Ruchat, Sophie Chaput-Langlois, et al. 2025. "
Associations Between Walking in the Third Trimester of Pregnancy and Maternal Mental Health During the COVID-19 Pandemic."
International Journal of Environmental Research and Public Health 22 (10): 1538. https://doi.org/10.3390/ijerph22101538.
Download
Khiat, Nihad, Julie Girouard, Emmanuelle Stella Kana Tsapi, Cathy Vaillancourt, Céline Van Themsche, and Carlos Reyes-Moreno. 2025. "
TGFβ1 Restores Energy Homeostasis of Human Trophoblast Cells Under Hyperglycemia In Vitro by Inducing PPARγ Expression, AMPK Activation, and HIF1α Degradation."
Cells 14 (1): 45. https://doi.org/10.3390/cells14010045.
Download