Mahdi Rahimi
Associé de Recherche
Recherche CIUSSS NÎM
Mahdi Rahimi (Ph.D.) is a driven researcher with a keen focus on designing innovative materials for drug and gene delivery systems. His current research trajectory at centre de recherche de l’Hôpital du Sacré-Cœur de Montréal is centered on developing targeted nano-vectors to combat the complexities of inflammatory diseases through gene therapy. His expertise in nano-formulation allows him to engineer nanovectors capable of efficiently and specifically delivering therapeutic genes. Prior to his current role, Mahdi delved deep into the world of bottlebrush polymers during his postdoctoral research at Lodz University of Technology, Poland. His work in this area focused on tailoring these unique polymers for biomedical applications, specifically osteoarthritis treatment and novel drug delivery systems. Mahdi's expertise lies in the intersection of chemistry and biology, specifically in the realm of polymer-based drug delivery systems. His strong foundation in organic chemistry enables him to design and synthesize innovative polymeric materials, while his proficiency in biological techniques allows him to evaluate their efficacy in biomedical applications. With a particular focus on nanotechnology, Mahdi excels in developing targeted drug delivery systems capable of overcoming biological barriers and improving therapeutic outcomes.
* Co-first Author
1. K. Turczyńska, M. Rahimi*, G. Charmi, D. A. Pham, H. Murata, M. Kozanecki, P. Filipczak, J. Ulański, T. Diem, K. Matyjaszewski, X Banquy, J. Pietrasik. Bottlebrush Polymers for Articular Joint Lubrication: Influence of Anchoring Group Chemistry on Lubrication Properties. ACS Appl. Mater. Interfaces, 2024.
https://doi.org/10.1021/acsami.4c07282
2. M. Rahimi*, M. Gałęziewska, K. Jerczyński, S. Wróbel, J. Pietrasik. Non‐linear functional polymers containing selective/cleavable bonds: Synthesis and their biomedical applications. Polymers for Advanced Technologies, 2024, 35(4):e6387.
https://doi.org/10.1002/pat.6387
3. Z. Kariminezhad, M. Rahimi, J. Fernandes, R. Maltais, J-Yves Sancéau, D. Poirier, H. Fahmi, M. Benderdour. Development of New Resolvin D1 Analogues for Osteoarthritis Therapy: Acellular and Computational Approaches to Study Their Antioxidant Activities. Antioxidants, 2024, 13, 386.
https://doi.org/10.3390/antiox13040386
4. G. Charmi, M. Rahimi*, K. Socha, D. A. Pham, L. Séguy, Q. T. Phan, F. Moldovan, M. Kozanecki, K. Matyjaszewski, X. Banquy, J. Pietrasik. Bottlebrush polymer with dual functionality for osteoarthritis treatment: curcumin delivery and lubrication properties. Polymer Chemistry, 2023, 14, 3827-3833.
https://doi.org/10.1039/D3PY00781B
5. Y. Zare, J. Soleymani, M. Rahimi, Y. Nuri Ertas, S. Jafarzadeh. Trends in advanced materials for the fabrication of insulin electrochemical immunosensors. Chemical Papers, 2022, 76(12), pp. 7263–7274.
https://doi.org/10.1007/s11696-022-02416-5
6. N. Targhazeh, R.J. Reiter, M. Rahimi, D. Qujeqe, T. Yousefi, Mohammad HassanShahavihSeyed MostafaMirOncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy. Biochimie, 2022, 202, pp. 34–48.
https://doi.org/10.1016/j.biochi.2022.06.008
7. M. Rahimi, S.M. Mir, R. Baghban, G. Charmi, C.M. Plummer, V. Shafiei-Irannejad, J. Soleymani, J. Pietrasik. Chitosan-based biomaterials for the treatment of bone disorders. International Journal of Biological Macromolecules, 2022, 215, pp. 346–367.
https://doi.org/10.1016/j.ijbiomac.2022.06.079
8. W. Raj, K. Jerczynski, M. Rahimi, E. Pavlova, M. Šlouf, A. Przekora, J. Pietrasik. Stimuli-responsive vitamin E-based micelles: Effective drug carriers with a controlled anticancer drug release. Polymer, 2022, 253, 125001.
https://doi.org/10.1016/j.polymer.2022.125001
9. M. Mahmoudpour, A. Jouyban, J. Soleymani, M. Rahimi. Rational design of smart nano-platforms based on antifouling-nanomaterials toward multifunctional bioanalysis. Advances in Colloid and Interface Science, 2022, 302, 102637.
https://doi.org/10.1016/j.cis.2022.102637
10. M. Molaparast, H. Malekinejad, M. Rahimi, V. Shafiei-Irannejad. Biocompatible functionalized graphene nanosheet for delivery of doxorubicin to breast cancer cells. Journal of Drug Delivery Science and Technology, 2022, 70, 103234.
https://doi.org/10.1016/j.jddst.2022.103234
11. A. Nakhlband, H. Kholafazad-Kordasht, M. Rahimi, A. Mokhtarzadeh, J. Soleymani. Applications of magnetic materials in the fabrication of microfluidic-based sensing systems: Recent advances. Microchemical Journal, 2022, 173, 107042
https://doi.org/10.1016/j.microc.2021.107042
12. R. Baghban, M. Afarid, J. Soleymani, M. Rahimi. Were magnetic materials useful in cancer therapy? Biomedicine and Pharmacotherapy, 2021, 144, 112321.
https://doi.org/10.1016/j.biopha.2021.112321
13. W. Raj, K. Jerczynski, M. Rahimi, A. Przekora, K. Matyjaszewski, J. Pietrasik. Molecular bottlebrush with pH-responsive cleavable bonds as a unimolecular vehicle for anticancer drug delivery. Materials Science and Engineering C, 2021, 130, 112439.
https://doi.org/10.1016/j.msec.2021.112439
14. M. Rahimi, G. Charmi, K. Matyjaszewski, X. Banquy, Joanna Pietrasik. Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis. Acta Biomaterialia, 2021, 123, 31-50.
https://doi.org/10.1016/j.actbio.2021.01.003
15. R. Shahvalizadeh, R. Ahmadi, I. Davandeh, A. Pezeshki, S. Amir, S. Moslemi, S. Karimi, M. Rahimi, H. Hamishehkar, M. Mohammadi. Antimicrobial bio-nanocomposite films based on gelatin, tragacanth, and zinc oxide nanoparticles- Microstructural, mechanical, thermo-physical, and barrier properties. Food Chemistry, 2021,
https://doi.org/10.1016/j.foodchem.2021.129492
16. M. Mahkam, F. Bazmi Zeynabad, E. Alizadeh, M. Rahimi, F. Rahimi, R. Salehi. Novel methotrexate-ciprofloxacin loaded alginate-clay based nanocomposite as anticancer and antibacterial co-drug delivery system. Advanced Pharmaceutical Bulletin, 2021, 11(3), 477–489.
https://dx.doi.org/10.34172%2Fapb.2021.055
17. A. Abolghassemi Fakhree, Z. Ghasemi, M. Rahimi, A. Shahrisa. Enhanced catalytic performance of copper iodide in 1,2,3‐triazole‐imidazole hybrid synthesis, and evaluation of their anti‐cancer activities along with optical properties besides 1H‐tetrazole‐imidazole hybrids. Applied Organometallic Chemistry, 2020, 34 (9), 5773.
https://doi.org/10.1002/aoc.5773
18. F. Alemi, R. Zarezadeh, A. Raei Sadigh, H. Hamishehkar, M. Rahimi, M. Majidinia, Z. Asemi, A. Ebrahimi-Kalan, B. Yousefi, N. Rashtchizadeh. Graphene Oxide and Reduced Graphene Oxide: Efficient Cargo Platforms for Cancer Theranostics. Journal of Drug Delivery Science and Technology, 2020, 60, 101974. https://doi.org/10.1016/j.jddst.2020.101974
19. S.M. Mir, B. Yousefi, A. Marjani, M. Rahimi, D. Qujeq. The sensitization of melatonin in osteosarcoma cells by suppression of anti-Apoptotic proteins. Pharmaceutical Sciences, 2020, 26(2), 159–164.
https://doi.org/10.34172/PS.2020.3
20. R. Rakhshaei, H. Namazi, H. Hamishehkar, M. Rahimi. Graphene quantum dot cross-linked carboxymethyl cellulose nanocomposite hydrogel for pH-sensitive oral anticancer drug delivery with potential bioimaging properties. International journal of biological macromolecules, 2020, 150, 1121-1129.
https://doi.org/10.1016/j.ijbiomac.2019.10.118
21. M. Majidinia, M. Mirza‐Aghazadeh‐Attari, M. Rahimi, A. Mihanfar, A. Karimian, A. Safa, B. Yousefi. Overcoming multidrug resistance in cancer: Recent progress in nanotechnology and new horizons. IUBMB life, 2020, 72 (5), 855-871.
https://doi.org/10.1002/iub.2215
22. E. Bahojb Noruzi, M. Molaparast, M. Zarei, B. Shaabani, Z. Kariminezhad, B. Ebadi, V. Shafiei-Irannejad, M. Rahimi*, J. Pietrasik. Para-sulfonatocalix [n] arene-based biomaterials: Recent progress in pharmaceutical and biological applications. European Journal of Medicinal Chemistry, 2020, 1190, 112121.
https://doi.org/10.1016/j.ejmech.2020.112121
23. M. Rahimi, E. Bahojb Noruzi, E. Sheykhsaran, B. Ebadi, Z. Kariminezhad, M. Molaparast, M. Ghanbari Mehrabani, B. Mehramouz, M. Yousefi, R. Ahmadi, B. Yousefi, K. Ganbarov, F. S Kamounah, V. Shafiei-Irannejad, H. Samadi Kafil. Carbohydrate polymer-based silver nanocomposites: Recent progress in the antimicrobial wound dressings. Carbohydrate Polymers, 2020, 231, 115696.
https://doi.org/10.1016/j.carbpol.2019.115696
24. D. Ahmadi, M. Zarei, M. Rahimi, M. Khazaie, Z. Asemi, S. M. Mir, A. Sadeghpour, A. Karimian, F. Alemi, M. Rahmati-Yamchi, R. Salehi, F. Jadidi-Niaragh, M. Yousefi, N. Khelgati, M. Majidinia, N. Sara, B. Yousefi. Preparation and in-vitro evaluation of pH-responsive cationic cyclodextrin coated magnetic nanoparticles for delivery of methotrexate to the Saos-2 bone cancer cells. Journal of Drug Delivery Science and Technology, 2020, 57, 101584.
https://doi.org/10.1016/j.jddst.2020.101584
25. Global Burden of Disease Stomach Cancer Collaborators. The global, regional, and national burden of stomach cancer in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease study 2017. The Lancet, 2020, 5 (1), 42-54.
https://doi.org/10.1016/S2468-1253(19)30328-0
26. Global Burden of Disease Cancer Collaboration. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncology, 2019, 5 (12), 1749-1768.
https://doi.org/10.1001/jamaoncol.2019.2996
27. Global Burden of Disease Pancreatic Cancer Collaborators. The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 2019, 4 (12), 934-947.
https://doi.org/10.1016/S2468-1253(19)30347-4
28. M. Rahimi, R. Ahmadi, H. Samadi Kafil, V. Shafiei-Irannejad. A novel bioactive quaternized chitosan and its silver-containing nanocomposites as a potent antimicrobial wound dressing: Structural and biological properties. Materials Science and Engineering: C, 2019, 101, 360-369.
https://doi.org/10.1016/j.msec.2019.03.092
29. M. Rahimi, R. Karimian, E. Bahojb Noruzi, K. Ganbarov, M. Zarei, F. S Kamounah, B. Yousefi, M. Bastami, M. Yousefi, H. Samadi Kafil. Needle-shaped amphoteric calix [4] arene as a magnetic nanocarrier for simultaneous delivery of anticancer drugs to the breast cancer cells. International Journal of Nanomedicine, 2019, 14, 2619-2636.
https://doi.org/10.2147/IJN.S194596
30. A. Karimian, H. Parsian, M. Majidinia, M. Rahimi, M. Mir, H. Samadi-Kafil, V. Shafiei-Irannejad, M. Kheyrollah, H. Ostadi, B. Yousefi. Nanocrystalline cellulose: Preparation, physicochemical properties, and applications in drug delivery systems. International Journal of Biological Macromolecules, 2019, 133, 850-859.
https://doi.org/10.1016/j.ijbiomac.2019.04.117
31. S. Bahrambeigi, M. Rahimi, B. Yousefi, V. Shafiei‐Irannejad. New potentials for 3‐hydroxy‐3‐methyl‐glutaryl‐coenzymeA reductase inhibitors: Possible applications in retarding diabetic complications. Journal of Cellular Physiology, 2019, 1-13.
https://doi.org/10.1002/jcp.28682
32. V. Shafiei-Irannejad, M. Rahimi*, M. Zarei, R. Dinparast-isaleh, S. Bahrambeigi, A. Alihemmati, S. Shojaei, Z. Ghasemi, B. Yousefi. Polyelectrolyte Carboxymethyl Cellulose for Enhanced Delivery of Doxorubicin in MCF7 Breast Cancer Cells: Toxicological Evaluations in Mice Model. Pharmaceutical Research, 2019, 36, 68-84.
https://doi.org/10.1007/s11095-019-2598-3
33. S. Bahrambeigi, B. Yousefi, M. Rahimi, V. Shafiei-Irannejad. Metformin; an old antidiabetic drug with new potentials in bone disorders. Biomedicine & Pharmacotherapy, 2019, 109, 10593-160.
https://doi.org/10.1016/j.biopha.2018.11.032
34. M. Rahimi, V. Shafiei-Irannejad, K. D. Safa and R. Salehi. Multi-branched ionic liquid-chitosan as a smart and biocompatible nano-vehicle for combination chemotherapy with stealth and targeted properties. Carbohydrate Polymers, 2018, 196, 299-312.
https://doi.org/10.1016/j.carbpol.2018.05.059
35. M. Ghanbari, R. Karimian, R. Rakhshaei, F. Pakdel, H. Eslamie, V. Fakhrzad, M. Rahimi R. Salehi and H. Samadi Kafil. Chitin/silk fibroin/TiO2 bio-nanocomposite as a biocompatible wound dressing bandage with strong antimicrobial activity. International Journal of Biological Macromolecules, 2018, 116, 966-976.
https://doi.org/10.1016/j.ijbiomac.2018.05.102
36. M. Ghanbari, R. Karimian, B. Mehramouz, M. Rahimi, H. Samadi Kafil. Preparation of biocompatible and biodegradable silk fibroin/chitin/silver nanoparticles 3D scaffolds as a bandage for antimicrobial wound dressing. International Journal of Biological Macromolecules, 2018, 114, 961-971.
https://doi.org/10.1016/j.ijbiomac.2018.03.128
37. V. Shafiei-Irannejad, N. Samadi, R. Salehi, B. Yousefi, M. Rahimi, A. Akbarzadeh and N. Zarghami Reversion of Multidrug Resistance by Co-Encapsulation of Doxorubicin and Metformin in Poly (lactide-co-glycolide)-d-α-tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles. Pharmaceutical Research, 2018, 35(6), 119-131.
https://doi.org/10.1007/s11095-018-2404-7
38. M. Rahimi, R. Karimian, E. Mostafidi, E. B. Noruzi, S. Taghizadeh, B. Shokouhi and H. Samadi Kafil. Highly branched amine-functionalized p-sulfonatocalix[4]arene decorated with human plasma proteins as a smart, targeted, and stealthy nano-vehicle for the combination chemotherapy of MCF7 cells. New Journal of Cehmistry, 2018, 42, 13010-13024.
https://doi.org/10.1039/C8NJ01790E
39. M. Rahimi, K. D.Safa, E. Alizadeh and R. Salehi. Dendritic chitosan as a magnetic and biocompatible nanocarrier for the simultaneous delivery of doxorubicin and methotrexate to MCF-7 cell line. New Journal of Cehmistry, 2017,41, 3177-3189.
https://doi.org/10.1039/C6NJ04107H
40. M. Rahimi, K. D. Safa and R. Salehi. Co-delivery of doxorubicin and methotrexate by dendritic chitosan-g-mPEG as a magnetic nanocarrier for multi-drug delivery in combination chemotherapy. Polymer Chemistry, 2017, 8(47), 7333-7350.
https://doi.org/10.1039/C7PY01701D
41. M. Rahimi, S. Shojaei, K. D. Safa, Z. Ghasemi, R. Salehi, B. Yousefi and V. Shafiei-Irannejad. Biocompatible magnetic tris (2-aminoethyl) amine functionalized nanocrystalline cellulose as a novel nanocarrier for anticancer drug delivery of methotrexate. New Journal of Chemistry, 2017, 41(5), 2160-2168.
https://doi.org/10.1039/C6NJ03332F
