Jonathan Brouillette

Jonathan Brouillette

Chercheur régulier
Hôpital du Sacré-Cœur-de-Montréal

Université de Montréal, Faculté de Médecine, Département de Pharmacologie et Physiologie

Neuroscience
Maladie d’Alzheimer
Vieillissement
Mémoire
Sommeil
Neurodégénérescence
Anesthésie
Phosphatase STEP
Oligomères amyloïde-bêta (Aβo)
Tau
Transthyrétine

2019 - Professeur sous octroi agrégé - Pharmacologie et Physiologie - Université de Montréal (Canada)
2016 - Professeur sous octroi adjoint - Pharmacologie et Physiologie - Université de Montréal (Canada)
2014 - Professeur-chercheur adjoint - Pharmacologie et Physiologie - Université de Montréal (Canada)
2014 - Chercheur régulier– Hôpital du Sacré-Coeur de Montréal (Canada)
2011 - Associé de Recherche - Neuroscience - Université Yale (USA)
2007 - Post-Doctorat - Neuroscience - Université de Lille 2 (France) et Université de Louvain (Belgique)
2001 - Ph.D. - Neuroscience - Université McGill (Canada)
1999 - M.Sc. - Neuroscience - Université de Montréal (Canada)
1996 - B.Sc. - Biochimie - Université de Montréal (Canada)

Dufort-Gervais J, Provost C, Charbonneau L, Norris C, Calon F, Mongrain V, Brouillette J (2020) Neuroligin-1 is altered in the hippocampus of Alzheimer’s disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers. Scientific Reports, 10: 6956

Hector A, McAnulty C, Piché-Lemieux MÉ, Alves-Pires C, Buée-Scherrer V, Buée L, Brouillette J (2020) Tau hyperphosphorylation induced by the anesthetic agent ketamine/xylazine involved the calmodulin-dependent protein kinase II. FASEB J, 34: 2968-2977

Dufort-Gervais J, Mongrain V, Brouillette J (2019) Bidirectional relationships between sleep and amyloid-beta in the hippocampus. Neurobiology of Learning and Memory, 160: 108-117

Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn A, Norris CM, Ferland G, Bézard E, Gaudreau P, Lombroso P, Brouillette J (2018). The tyrosine phosphatase STEP is involved in age-related memory decline. Current Biology, 28: 1079-1089

Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Tautz L, Nairn AC, Ellman JA, Lombroso PJ (2014) Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer’s disease. PLoS Biology, 12: e1001923

Brouillette J (2014) The effects of soluble Aβ oligomers on neurodegeneration in Alzheimer’s disease. Current Pharmaceutical Design, 20: 2506-2519

Carty N, Xu J, Kurup P, Brouillette J, Goebel-Goody SM, Austin DR, Yuan P, Chen G, Correa PR, Pittenger C, Lombroso P (2012) The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications. Translational Psychiatry, 2: e137 1-11

Brouillette J, Caillierez R, Zommer N, Alves-Pires C, Benilova I, Blum D, De Strooper B, Buée L (2012) Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model. Journal of Neuroscience, 32: 7852–7861

Le Freche H*, Brouillette J* [First Co-Author], Fernandez-Gomez F, Patin P, Caillierez R, Zommer N, Sergeant N, Buée-Scherrer V, Lebuffe G, Blum D, Buée L (2012) Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment. Anesthesiology, 116: 779-787

Benoit CE, Bastianetto S, Brouillette J, Tse Y, Boutin JA, Delagrange P, Wong T, Sarret P, Quirion R (2010) Loss of quinone reductase 2 function selectively facilitates learning behaviors. Journal of Neuroscience, 30: 12690-12700

Brouillette J, Quirion R (2008) Transthyretin: a key gene involved in the maintenance of memory capacities during aging. Neurobiology of Aging, 29: 1721-1732

Brouillette J, Young D, During MJ, Quirion R (2007) Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABAB receptors in scopolamine-induced amnesia. Journal of Neurochemistry, 102: 1978-1989