Mariane Bertagnolli

Chercheuse régulière
Hôpital du Sacré-Cœur-de-Montréal

Assistant Professor
Université McGill

Chercheuse régulière
Hôpital en santé mentale Rivière-des-Prairies

Professeure associée, École de kinésiologie et sciences de l'activité physique, Faculté de Médecine, Université de Montréal

Visiting researcher, Cardiovascular Division, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

Dre Mariane Bertagnolli détient un baccalauréat en physiothérapie (Universidade Federal de Santa Maria, Brésil) et a complété ses formations de maîtrise et doctorat en physiologie dans le laboratoire de la Dre Maria Claudia Irigoyen à l’Universidade Federal do Rio Grande do Sul, Brésil (2008). Elle a ensuite effectué une formation en recherche à l’Instituto de Cardiologia de Porto Alegre, Brésil (2009) suivi des formations post-doctorales dans le laboratoire de la Dre Anne Monique Nuyt, au CHU Sainte-Justine (Université de Montréal, Canada), jusqu’en 2015, et à l’Hôpital John Radcliffe (University of Oxford, Royaume-Uni), sous la direction du Prof Paul Leeson (2016-2017). Depuis 2018, Dre Bertagnolli a établi son laboratoire de recherche à l’Hôpital du Sacré-Coeur de Montréal au CIUSSS-NÎM en tant que chercheure régulière et professeure assistante à École de physiothérapie et d'ergothérapie de l’Université McGill. Ses recherches visent à comprendre l'impact des l’inactivité physique et des troubles de la grossesse liés à l'hypertension, tels que la prééclampsie, sur la santé des femmes et des enfants. En particulier, elle étudie les cellules endothéliales et les modifications de l'angiogenèse dans le placenta et leur impact sur le développement fœtal. Son laboratoire développe des études sur des modèles expérimentaux, cellulaires et cliniques, axées sur la découverte de nouveaux traitements visant à améliorer le développement placentaire et la microcirculation dans les grossesses hypertendues, dans le but de prévenir les maladies cardiovasculaires chez les femmes et les enfants.

Publications

Guzzoni, Vinicius, Isabel Cristina Mallosto Emerich de Abreu, Mariane Bertagnolli, Roberta Hack Mendes, Adriane Belló-Klein, Dulce Elena Casarini, Karin Flues, et al. 2024. “Aerobic Training Increases Renal Antioxidant Defence and Reduces Angiotensin II Levels, Mitigating the High Mortality in SHR-STZ Model.” Archives of Physiology and Biochemistry 130 (6): 992–1004. https://doi.org/10.1080/13813455.2024.2377381.
Nieves, Cecilia, Paola Victoria da Costa Ghignatti, Narjiss Aji, and Mariane Bertagnolli. 2024. “Immune Cells and Infectious Diseases in Preeclampsia Susceptibility.” The Canadian Journal of Cardiology 40 (12): 2340–55. https://doi.org/10.1016/j.cjca.2024.09.012.
Pongpanit, Karan, Natalie Dayan, Tania Janaudis-Ferreira, Marc Roig, Jadranka Spahija, and Mariane Bertagnolli. 2024. “Exercise Effects on Maternal Vascular Health and Blood Pressure during Pregnancy and Postpartum: A Systematic Review and Meta-Analysis.” European Journal of Preventive Cardiology 31 (13): 1606–20. https://doi.org/10.1093/eurjpc/zwae165.
Guzzoni, Vinicius, Isabel Cristina Mallosto Emerich de Abreu, Mariane Bertagnolli, Roberta Hack Mendes, Adriane Belló-Klein, Dulce Elena Casarini, Karin Flues, et al. 2024. “Aerobic Training Increases Renal Antioxidant Defence and Reduces Angiotensin II Levels, Mitigating the High Mortality in SHR-STZ Model.” Archives of Physiology and Biochemistry, July, 1–13. https://doi.org/10.1080/13813455.2024.2377381.
Pongpanit, Karan, Natalie Dayan, Tania Janaudis-Ferreira, Marc Roig, Jadranka Spahija, and Mariane Bertagnolli. 2024. “Exercise Effects on Maternal Vascular Health and Blood Pressure during Pregnancy and Postpartum: A Systematic Review and Meta-Analysis.” European Journal of Preventive Cardiology, May, zwae165. https://doi.org/10.1093/eurjpc/zwae165.
Bertagnolli, Mariane. 2024. “Mitigating Preeclampsia Risk through Effective Uncontrolled Blood Pressure Management.” Hypertension Research : Official Journal of the Japanese Society of Hypertension 47 (2): 545–47. https://doi.org/10.1038/s41440-023-01489-3.
Bertagnolli, Mariane. 2024. “Mitigating Preeclampsia Risk through Effective Uncontrolled Blood Pressure Management.” Hypertension Research : Official Journal of the Japanese Society of Hypertension 47 (2): 545–47. https://doi.org/10.1038/s41440-023-01489-3.
Delfrate, Jacques, Camille Girard-Bock, Daniel Curnier, Delphine Périé-Curnier, Anik Cloutier, Gabrielle Gascon, Jennifer S. Landry, et al. 2023. “Cardiopulmonary Response to Exercise in Adults Born Very Preterm.” The European Respiratory Journal 62 (5): 2300503. https://doi.org/10.1183/13993003.00503-2023.
Burchert, Holger, Winok Lapidaire, Wilby Williamson, Annabelle McCourt, Cameron Dockerill, William Woodward, Cheryl M. J. Tan, et al. 2023. “Aerobic Exercise Training Response in Preterm-Born Young Adults with Elevated Blood Pressure and Stage 1 Hypertension: A Randomized Clinical Trial.” American Journal of Respiratory and Critical Care Medicine 207 (9): 1227–36. https://doi.org/10.1164/rccm.202205-0858OC.
Alexander, Barbara T., Andrew M. South, Phyllis August, Mariane Bertagnolli, Erin P. Ferranti, Justin L. Grobe, Emily J. Jones, Analia S. Loria, Basmah Safdar, and Maria Luisa Soledad Sequeira-Lopez. 2023. “Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and  Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward:  A Scientific Statement From the American Heart Association.” Hypertension (Dallas, Tex. : 1979) 80 (5): e75–89. https://doi.org/10.1161/HYP.0000000000000227.
- Troubles hypertensifs de la grossesse et la programmation fœtale de maladies cardiaques
- Mécanismes d'angiogenèse dans le développement placentaire.
- Déterminants socioéconomiques du comportement sédentaire et de la santé des femmes.
- Réadaptation cardiaque et obstétrique.

B.Sc. en Physiothérapie, Universidade Federal de Santa Maria, Brésil
M.Sc. en Physiologie, Universidade Federal do Rio Grande do Sul, Brésil
Ph.D. en Physiologie, Universidade Federal do Rio Grande do Sul, Brésil
Stage postdoctoral en Sciences biomédicales, CHU Sainte-Justine, Université de Montréal, Canada
Stage postdoctoral en Médecine cardiovasculaire, University of Oxford, Royaume-Uni

Huckstep OJ, Burchert H, Williamson W, Telles F, Tan CMJ, Bertagnolli M, Arnold L, Mohamed A, McCormick K, Hanssen H, Leeson P, Lewandowski AJ (2020). Impaired myocardial reserve underlies reduced exercise capacity and heart rate recovery in preterm-born young adults. Eur Heart J Cardiovasc Imaging. jeaa060. doi: 10.1093/ehjci/jeaa060.

Raguema N, Moustadraf S, Bertagnolli M (2020). Immune and Apoptosis Mechanisms Regulating Placental Development and Vascularization in Preeclampsia. Front Physiol. 11;11:98. doi: 10.3389/fphys.2020.00098.

Raguema N, Bertagnolli M (2018). Renin angiotensin system in heart development and diseases across lifespan. Revista Hipertensao. 21(3):26-32.

Williamson W, Huckstep O, Frangou E, Mohamed A, Tan C, Alsharqi M, Bertagnolli M, Lapidaire W, Newton J, Hanssen H, McManus R, Dawes H, Foster C, Lewandowski A, Leeson P (2018). Trial of Exercise to Prevent HypeRtension in young Adults (TEPHRA) a randomized controlled trial: Study Protocol. BMC Cardiovascular Disorders.18(1):208.

Huckstep OJ, Williamson W, Telles F, Burchert H, Bertagnolli M, Herdman C, Arnold L, Smillie R, Mohamed A, Boardman H, McCormick K, Leeson P, Lewandowski AJ (2018). Physiological stress elicits impaired left ventricular function in preterm-born adults. Journal of the American College of Cardiology (JACC). 71(12):1347-1356. 15

Bertagnolli M, Xie L, Paquette K, He Y, Cloutier A, Delfrate J, Curnier D, Lukaszewski MA, Sutherland M, Bigras JL, Thebaud B, Rivard, A, Luu TM, Nuyt AM (2018). Endothelial colony- forming cells in preterm born young adults: A novel link between neonatal complications and adult risks to cardiovascular diseases. Journal of the American Heart Association, J Am Heart Assoc. 7(14). pii: e009720

Bertagnolli M (2017). Preterm birth and renin-angiotensin-aldosterone system: Evidences of activation and impact on developmental cardiovascular disease risks. Protein & Peptide Letters. 17;24(9):793-798

Bertagnolli M, Nuyt AM, Thebaud B, Luu TM (2017). Endothelial progenitor cells as prognostic markers of preterm birth-associated complications. Stem Cells Translational Medicine. 6(1):7-13 (perspective paper)

Bertagnolli M, Luu TM, Lewandowski AJ, Leeson P, Nuyt AM (2016). preterm birth and hypertension: Is there a link? Current Hypertension Reports. 18(4):28

Bertagnolli M, Dios A, Béland-Bonenfant S, Gascon G, Sutherland M, Lukaszewski MA, Cloutier A, Paradis P, Schiffrin EL, Nuyt AM (2016). Activation of the cardiac renin-angiotensin system in high oxygen-exposed newborn rats: Angiotensin receptor blockade prevents the developmental programming of cardiac dysfunction. Hypertension. 67(4):774-82

Bertagnolli M, Huyard F, Cloutier A, Anstey Z, Huot-Marchand JÉ, Fallaha C, Paradis P, Schiffrin EL, Deblois D, Nuyt AM (2014). Transient neonatal high oxygen exposure leads to early adult cardiac dysfunction, remodeling and activation of the renin angiotensin system. Hypertension. 63(1):143-50

Bertagnolli M, Casali KR, De Sousa FB, Rigatto K, Becker L, Santos SH, Dias LD, Pinto G, Dartora DR, Schaan BD, Milan RD, Irigoyen MC, Santos RA (2014). An orally active angiotensin-(1-7) inclusion compound and exercise training produce similar cardiovascular effects in spontaneously hypertensive rats. Peptides. 51:65-73

Bertagnolli M, Schenkel PC, Campos C, Mostarda C, Casarini DE, Belló-Klein A, Irigoyen MC, Rigatto K (2008). Exercise training reduces sympathetic modulation on cardiovascular system and cardiac oxidative stress in spontaneously hypertensive rats. American Journal of Hypertension. 21(11):1188-93

Bertagnolli M, Campos C, Schenkel PC, de Oliveira VL, De Angelis K, Belló-Klein A, Rigatto K, Irigoyen MC (2006). Baroreflex sensitivity improvement is associated with decreased oxidative stress in trained spontaneously hypertensive rats. Journal of Hypertension. 24(12):2437-43

Pubmed publications

- "Sex-differences in fetal programming of cardiomyopathy induced by hypertensive disorders of pregnancy in mice" (2019). 2019 Hypertension Scientific Sessions, Nouvelle Orléans, U.S.A.

- “Renin angiotensin system in cardiovascular disease across lifespan: “A dual or dueling role?”. Congress of the Brazilian Hypertension Society (Sociedade Brasileira de Hipertensão, SBH) 2018, São José do Rio Preto, Brésil

- “Like mother, like child – maternal health and heart disease” (2017). SciBar, Oxford British Science Association, Oxford Women’s International Festival, Oxford, Royaume-Uni

- “Angiotensin-(1-7) and alamandine prevent the developmental programming of cardiac dysfunction induced by neonatal hyperoxic stress” (2016). Gordon Research Seminars: Angiotensin, Lucca (Braga), Italie

- “Transient neonatal high oxygen exposure and cardiovascular changes in early adult life” (2014). Pregnancy Complications and Offspring Symposium, Wolfson College, University of Oxford, Oxford, Royaume-Uni

- SickKids Foundation
- CIUSSS Nord-de-l'Île-de-Montréal
- Société Québécoise d'Hypertension Artérielle - Servier
- Instituts de recherche en Santé du Canada
- British Hear Foundation