Mariane Bertagnolli

Chercheuse régulière
Hôpital du Sacré-Cœur-de-Montréal

Assistant Professor
Université McGill

Chercheuse régulière
Hôpital en santé mentale Rivière-des-Prairies

Professeure associée, École de kinésiologie et sciences de l'activité physique, Faculté de Médecine, Université de Montréal

Visiting researcher, Cardiovascular Division, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

Dre Mariane Bertagnolli détient un baccalauréat en physiothérapie (Universidade Federal de Santa Maria, Brésil) et a complété ses formations de maîtrise et doctorat en physiologie dans le laboratoire de la Dre Maria Claudia Irigoyen à l’Universidade Federal do Rio Grande do Sul, Brésil (2008). Elle a ensuite effectué une formation en recherche à l’Instituto de Cardiologia de Porto Alegre, Brésil (2009) suivi des formations post-doctorales dans le laboratoire de la Dre Anne Monique Nuyt, au CHU Sainte-Justine (Université de Montréal, Canada), jusqu’en 2015, et à l’Hôpital John Radcliffe (University of Oxford, Royaume-Uni), sous la direction du Prof Paul Leeson (2016-2017). Depuis 2018, Dre Bertagnolli a établi son laboratoire de recherche à l’Hôpital du Sacré-Coeur de Montréal au CIUSSS-NÎM en tant que chercheure régulière et professeure assistante à École de physiothérapie et d'ergothérapie de l’Université McGill. Ses recherches visent à comprendre l'impact des l’inactivité physique et des troubles de la grossesse liés à l'hypertension, tels que la prééclampsie, sur la santé des femmes et des enfants. En particulier, elle étudie les cellules endothéliales et les modifications de l'angiogenèse dans le placenta et leur impact sur le développement fœtal. Son laboratoire développe des études sur des modèles expérimentaux, cellulaires et cliniques, axées sur la découverte de nouveaux traitements visant à améliorer le développement placentaire et la microcirculation dans les grossesses hypertendues, dans le but de prévenir les maladies cardiovasculaires chez les femmes et les enfants.

Publications

Lewandowski, Adam J., Betty Raman, Mariane Bertagnolli, Afifah Mohamed, Wilby Williamson, Joana Leal Pelado, Angus McCance, Winok Lapidaire, Stefan Neubauer, and Paul Leeson. 2021. “Association of Preterm Birth With Myocardial Fibrosis and Diastolic Dysfunction in Young Adulthood.” Journal of the American College of Cardiology 78 (7): 683–92. https://doi.org/10.1016/j.jacc.2021.05.053. Download
Azinheira Nobrega Cruz, Nayara, Danielle Stoll, Dulce Elena Casarini, and Mariane Bertagnolli. 2021. “Role of ACE2 in Pregnancy and Potential Implications for COVID-19 Susceptibility.” Clinical Science (London, England: 1979) 135 (15): 1805–24. https://doi.org/10.1042/CS20210284. Download
Jama, Hamdi A., Rikeish R. Muralitharan, Chudan Xu, Joanne A. O’Donnell, Mariane Bertagnolli, Bradley R. S. Broughton, Geoffrey A. Head, and Francine Z. Marques. 2021. “Rodent Models of Hypertension.” British Journal of Pharmacology, August. https://doi.org/10.1111/bph.15650.
Tan, Cheryl M. J., Adam J. Lewandowski, Wilby Williamson, Odaro J. Huckstep, Grace Z. Yu, Roman Fischer, Jillian N. Simon, et al. 2021. “Proteomic Signature of Dysfunctional Circulating Endothelial Colony-Forming Cells of Young Adults.” Journal of the American Heart Association 10 (15): e021119. https://doi.org/10.1161/JAHA.121.021119. Download
Benizri, Nissim, Casandra Marc, Allahnah Achille, Nozha Raguema, Émilie Pepin, Julie L. Lavoie, and Mariane Bertagnolli. 2021. “Ultrasound Imaging of Remodeling in Fetal Mouse Heart and the Programming of Cardiomyopathy in Offspring of Superimposed Preeclampsia.” Hypertension (Dallas, Tex.: 1979) 77 (5): e47–49. https://doi.org/10.1161/HYPERTENSIONAHA.121.16959.
Huckstep, Odaro J., Holger Burchert, Wilby Williamson, Fernando Telles, Cheryl M. J. Tan, Mariane Bertagnolli, Linda Arnold, et al. 2021. “Impaired Myocardial Reserve Underlies Reduced Exercise Capacity and Heart Rate Recovery in Preterm-Born Young Adults.” European Heart Journal. Cardiovascular Imaging 22 (5): 572–80. https://doi.org/10.1093/ehjci/jeaa060. Download
Huckstep, Odaro J., Holger Burchert, Wilby Williamson, Fernando Telles, Cheryl M. J. Tan, Mariane Bertagnolli, Linda Arnold, et al. 2020. “Impaired Myocardial Reserve Underlies Reduced Exercise Capacity and Heart Rate Recovery in Preterm-Born Young Adults.” European Heart Journal Cardiovascular Imaging. https://doi.org/10.1093/ehjci/jeaa060. Download Download
Raguema, Nozha, Sarah Moustadraf, and Mariane Bertagnolli. 2020. “Immune and Apoptosis Mechanisms Regulating Placental Development and Vascularization in Preeclampsia.” Frontiers in Physiology 11: 98. https://doi.org/10.3389/fphys.2020.00098. Download
Raguema, Nozha, Sarah Moustadraf, C Marc, J Lavoie, Guy Rousseau, and Mariane Bertagnolli. 2020. “Évaluation de l’implication de l’apoptose dans le développement du prééclampsie.” Presented at the 28 Réunion Scientifique Annuelle de la Société Québécoise d’Hypertension Artérielle, Montréal, Canada.
Flahault, A, K Paquette, R Fernandes, J Delfrate, A Cloutier, M Henderson, JC Lavoie, et al. 2020. “Increased Incidence but Lack of Association Between Cardiovascular Risk Factors in Adults Born Preterm.” Hypertension. https://doi.org/10.1161/HYPERTENSIONAHA.119.14335.
- Troubles hypertensifs de la grossesse et la programmation fœtale de maladies cardiaques
- Mécanismes d'angiogenèse dans le développement placentaire.
- Déterminants socioéconomiques du comportement sédentaire et de la santé des femmes.
- Réadaptation cardiaque et obstétrique.

B.Sc. en Physiothérapie, Universidade Federal de Santa Maria, Brésil
M.Sc. en Physiologie, Universidade Federal do Rio Grande do Sul, Brésil
Ph.D. en Physiologie, Universidade Federal do Rio Grande do Sul, Brésil
Stage postdoctoral en Sciences biomédicales, CHU Sainte-Justine, Université de Montréal, Canada
Stage postdoctoral en Médecine cardiovasculaire, University of Oxford, Royaume-Uni

Huckstep OJ, Burchert H, Williamson W, Telles F, Tan CMJ, Bertagnolli M, Arnold L, Mohamed A, McCormick K, Hanssen H, Leeson P, Lewandowski AJ (2020). Impaired myocardial reserve underlies reduced exercise capacity and heart rate recovery in preterm-born young adults. Eur Heart J Cardiovasc Imaging. jeaa060. doi: 10.1093/ehjci/jeaa060.

Raguema N, Moustadraf S, Bertagnolli M (2020). Immune and Apoptosis Mechanisms Regulating Placental Development and Vascularization in Preeclampsia. Front Physiol. 11;11:98. doi: 10.3389/fphys.2020.00098.

Raguema N, Bertagnolli M (2018). Renin angiotensin system in heart development and diseases across lifespan. Revista Hipertensao. 21(3):26-32.

Williamson W, Huckstep O, Frangou E, Mohamed A, Tan C, Alsharqi M, Bertagnolli M, Lapidaire W, Newton J, Hanssen H, McManus R, Dawes H, Foster C, Lewandowski A, Leeson P (2018). Trial of Exercise to Prevent HypeRtension in young Adults (TEPHRA) a randomized controlled trial: Study Protocol. BMC Cardiovascular Disorders.18(1):208.

Huckstep OJ, Williamson W, Telles F, Burchert H, Bertagnolli M, Herdman C, Arnold L, Smillie R, Mohamed A, Boardman H, McCormick K, Leeson P, Lewandowski AJ (2018). Physiological stress elicits impaired left ventricular function in preterm-born adults. Journal of the American College of Cardiology (JACC). 71(12):1347-1356. 15

Bertagnolli M, Xie L, Paquette K, He Y, Cloutier A, Delfrate J, Curnier D, Lukaszewski MA, Sutherland M, Bigras JL, Thebaud B, Rivard, A, Luu TM, Nuyt AM (2018). Endothelial colony- forming cells in preterm born young adults: A novel link between neonatal complications and adult risks to cardiovascular diseases. Journal of the American Heart Association, J Am Heart Assoc. 7(14). pii: e009720

Bertagnolli M (2017). Preterm birth and renin-angiotensin-aldosterone system: Evidences of activation and impact on developmental cardiovascular disease risks. Protein & Peptide Letters. 17;24(9):793-798

Bertagnolli M, Nuyt AM, Thebaud B, Luu TM (2017). Endothelial progenitor cells as prognostic markers of preterm birth-associated complications. Stem Cells Translational Medicine. 6(1):7-13 (perspective paper)

Bertagnolli M, Luu TM, Lewandowski AJ, Leeson P, Nuyt AM (2016). preterm birth and hypertension: Is there a link? Current Hypertension Reports. 18(4):28

Bertagnolli M, Dios A, Béland-Bonenfant S, Gascon G, Sutherland M, Lukaszewski MA, Cloutier A, Paradis P, Schiffrin EL, Nuyt AM (2016). Activation of the cardiac renin-angiotensin system in high oxygen-exposed newborn rats: Angiotensin receptor blockade prevents the developmental programming of cardiac dysfunction. Hypertension. 67(4):774-82

Bertagnolli M, Huyard F, Cloutier A, Anstey Z, Huot-Marchand JÉ, Fallaha C, Paradis P, Schiffrin EL, Deblois D, Nuyt AM (2014). Transient neonatal high oxygen exposure leads to early adult cardiac dysfunction, remodeling and activation of the renin angiotensin system. Hypertension. 63(1):143-50

Bertagnolli M, Casali KR, De Sousa FB, Rigatto K, Becker L, Santos SH, Dias LD, Pinto G, Dartora DR, Schaan BD, Milan RD, Irigoyen MC, Santos RA (2014). An orally active angiotensin-(1-7) inclusion compound and exercise training produce similar cardiovascular effects in spontaneously hypertensive rats. Peptides. 51:65-73

Bertagnolli M, Schenkel PC, Campos C, Mostarda C, Casarini DE, Belló-Klein A, Irigoyen MC, Rigatto K (2008). Exercise training reduces sympathetic modulation on cardiovascular system and cardiac oxidative stress in spontaneously hypertensive rats. American Journal of Hypertension. 21(11):1188-93

Bertagnolli M, Campos C, Schenkel PC, de Oliveira VL, De Angelis K, Belló-Klein A, Rigatto K, Irigoyen MC (2006). Baroreflex sensitivity improvement is associated with decreased oxidative stress in trained spontaneously hypertensive rats. Journal of Hypertension. 24(12):2437-43

Pubmed publications

- "Sex-differences in fetal programming of cardiomyopathy induced by hypertensive disorders of pregnancy in mice" (2019). 2019 Hypertension Scientific Sessions, Nouvelle Orléans, U.S.A.

- “Renin angiotensin system in cardiovascular disease across lifespan: “A dual or dueling role?”. Congress of the Brazilian Hypertension Society (Sociedade Brasileira de Hipertensão, SBH) 2018, São José do Rio Preto, Brésil

- “Like mother, like child – maternal health and heart disease” (2017). SciBar, Oxford British Science Association, Oxford Women’s International Festival, Oxford, Royaume-Uni

- “Angiotensin-(1-7) and alamandine prevent the developmental programming of cardiac dysfunction induced by neonatal hyperoxic stress” (2016). Gordon Research Seminars: Angiotensin, Lucca (Braga), Italie

- “Transient neonatal high oxygen exposure and cardiovascular changes in early adult life” (2014). Pregnancy Complications and Offspring Symposium, Wolfson College, University of Oxford, Oxford, Royaume-Uni

- SickKids Foundation
- CIUSSS Nord-de-l'Île-de-Montréal
- Société Québécoise d'Hypertension Artérielle - Servier
- Instituts de recherche en Santé du Canada
- British Hear Foundation